Atenolol (versus unexposed)

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Delteil, 2024 11.78[0.53; 5.93]4,05774not evaluable Atrial septal defect Caton, 2009 10.90[0.10; 7.95]1,1376not evaluable Coarctation of aorta Caton, 2009 12.40[0.16; 35.19]4066not evaluable Congenital heart defects Caton, 2009 11.90[0.63; 5.70]5,02116not evaluable Ebstein's anomaly Caton, 2009 18.13[0.43; 152.49]655not evaluable Hypospadias Van Zutphen, 2014 10.86[0.26; 2.83]2,13115not evaluable Major congenital malformations Delteil, 2024 11.78[0.53; 5.93]4,05774not evaluable Pulmonary valve stenosis Caton, 2009 14.20[0.49; 36.01]5347not evaluable Growth parameters and prematurity Small for gestational age (weight) Lydakis, 1999 Bayliss, 2002 Orbach, 2013 Tanaka, 2016 Duan, 2018 Fitton (Controls unexposed, sick), 2020 Albertini, 2023 Delteil, 2024 82.78[2.23; 3.46]49,3451,038serious Low birth weight (< 2500g) Orbach, 2013 Ishibashi, 2017 Duan, 2018 34.01[3.33; 4.83]29,549746not evaluable Preterm (< 37 weeks) Lydakis, 1999 Orbach, 2013 22.70[1.75; 4.17]7,894185not evaluable Very low birth weight (< 1500g) Duan, 2018 14.21[2.80; 6.34]3,465638not evaluable Maternal consequences Preeclampsia Lydakis, 1999 Bayliss, 2002 Orbach, 2013 Duan, 2018 42.10[0.64; 6.88]3,543863not evaluable Caesarean Lydakis, 1999 Darcie, 2004 Duan, 2018 32.48[2.13; 2.88]104,581756not evaluable Assisted deliveries (forceps, vacuum, ...) Darcie, 2004 Duan, 2018 21.38[0.89; 2.12]8,259678not evaluable Neonatal disorders Low Apgar score (< 7) (at 1 min) Darcie, 2004 Orbach, 2013 Duan, 2018 32.02[1.43; 2.84]22,618785not evaluable Low Apgar score (< 7) (at 5 min) Darcie, 2004 Orbach, 2013 Duan, 2018 31.75[0.53; 5.79]4,064785not evaluable Neonatal hypoglycemia Darcie, 2004 Bateman, 2016 22.22[0.80; 6.15]1191,161not evaluable Low Apgar score (< 7) (at 10 min) Duan, 2018 12.06[0.85; 4.97]1,435638not evaluable Neonatal bradycardia Bateman, 2016 11.16[0.60; 2.26]431,121not evaluable Very low Apgar score (< 5) (at 1 min) Darcie, 2004 11.80[0.08; 39.94]240not evaluable Intrauterine deaths Late intrauterine deaths (> 22 weeks) Lydakis, 1999 11.17[0.23; 5.99]678not evaluable Perinatal death Orbach, 2013 10.33[0.02; 5.28]1,379107not evaluable0.0100.01.0

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