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Timolol (Ocular route only) (versus unexposed)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Pellegrino, 2018
1
0.71
[
0.04
; 13.34]
5
22
not evaluable
Major congenital malformations
Pellegrino, 2018
1
0.71
[
0.04
; 13.34]
5
22
not evaluable
Growth parameters and prematurity
Low birth weight (< 2500g)
Pellegrino, 2018
1
1.06
[
0.23
; 4.98]
17
22
not evaluable
Preterm (< 37 weeks)
Pellegrino, 2018
1
1.04
[
0.12
; 8.82]
8
24
not evaluable
Maternal consequences
Caesarean
Pellegrino, 2018
1
3.28
[
1.29
; 8.32]
91
24
not evaluable
Gestational diabetes
Pellegrino, 2018
1
2.80
[
0.69
; 11.27]
11
27
not evaluable
Preeclampsia
Pellegrino, 2018
1
1.40
[
0.16
; 12.46]
6
27
not evaluable
Neonatal disorders
Neonatal death (< 28 days of life)
Pellegrino, 2018
1
7.04
[
0.14
; 362.25]
-
27
not evaluable
Neonatal medical care
Pellegrino, 2018
1
8.24
[
0.50
; 136.65]
2
22
not evaluable
Intrauterine deaths
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions
Pellegrino, 2018
1
2.21
[
0.57
; 8.61]
13
27
not evaluable
Elective/induced termination of pregnancy
Pellegrino, 2018
1
0.99
[
0.05
; 19.69]
3
27
not evaluable
Late intrauterine deaths (> 22 weeks) / Stillbirths
Pellegrino, 2018
1
38.06
[
1.77
; 816.22]
2
27
not evaluable
0.0
100.0
1.0