Timolol (Ocular route only) (versus unexposed)

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Pellegrino, 2018 10.71[0.04; 13.34]522not evaluable Major congenital malformations Pellegrino, 2018 10.71[0.04; 13.34]522not evaluable Growth parameters and prematurity Low birth weight (< 2500g) Pellegrino, 2018 11.06[0.23; 4.98]1722not evaluable Preterm (< 37 weeks) Pellegrino, 2018 11.04[0.12; 8.82]824not evaluable Maternal consequences Caesarean Pellegrino, 2018 13.28[1.29; 8.32]9124not evaluable Gestational diabetes Pellegrino, 2018 12.80[0.69; 11.27]1127not evaluable Preeclampsia Pellegrino, 2018 11.40[0.16; 12.46]627not evaluable Neonatal disorders Neonatal death (< 28 days of life) Pellegrino, 2018 17.04[0.14; 362.25]-27not evaluable Neonatal medical care Pellegrino, 2018 18.24[0.50; 136.65]222not evaluable Intrauterine deaths Early intrauterine deaths (< 22 weeks) / Spontaneous abortions Pellegrino, 2018 12.21[0.57; 8.61]1327not evaluable Elective/induced termination of pregnancy Pellegrino, 2018 10.99[0.05; 19.69]327not evaluable Late intrauterine deaths (> 22 weeks) / Stillbirths Pellegrino, 2018 138.06[1.77; 816.22]227not evaluable0.0100.01.0