Ondansetron

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Einarson (Unexposed control), 2004 Andersen, 2013 Ozdemirci, 2014 Danielsson, 2014 Fejzo (Unexposed control, disease free), 2016 Huybrechts (Unexposed control), 2018 Bérard, 2019 Huybrechts, 2019 81.04[0.96; 1.12]167,592116,161not evaluable Cleft lip with or without cleft palate Anderka, 2012 Pasternak, 2013 Fejzo (Unexposed control, disease free), 2016 Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 Parker, NBDPS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 71.03[0.88; 1.21]4,58592,238not evaluable Congenital heart defects Andersen, 2013 Danielsson, 2014 Fejzo (Unexposed control, disease free), 2016 Huybrechts (Unexposed control), 2018 Zambelli-Weiner (Unexposed control, sick), 2019 Huybrechts, 2019 61.13[0.96; 1.33]59,616116,155not evaluable Major congenital malformations Einarson (Unexposed control), 2004 Colvin, 2013 Andersen, 2013 Danielsson, 2014 Huybrechts (Unexposed control), 2018 Bérard, 2019 Huybrechts, 2019 71.02[0.99; 1.05]150,947115,320not evaluable Ventricular septal defect Pasternak, 2013 Fejzo (Unexposed control, disease free), 2016 Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 Parker, NBDPS study, 2018 Lemon, 2019 Zambelli-Weiner (Unexposed control, NOS), 2019 71.13[0.99; 1.27]19,11096,086not evaluable Cleft palate Anderka, 2012 Pasternak, 2013 Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 Parker, NBDPS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 61.26[0.87; 1.82]3,36391,261not evaluable Oro-facial clefts Pasternak, 2013 Huybrechts (Unexposed control), 2018 Huybrechts, 2019 Zambelli-Weiner (Unexposed control, sick), 2019 41.20[1.02; 1.40]3,506113,549not evaluable Atrial septal defect Pasternak, 2013 Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 Parker, NBDPS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 51.05[0.79; 1.39]5,71591,265not evaluable Atrioventricular septal defect Pasternak, 2013 Huybrechts (Unexposed control), 2018 Parker, NBDPS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 41.38[0.65; 2.93]6,19090,765not evaluable Club foot / Talipes equinovarus Pasternak, 2013 Werler, 2014 Fejzo (Unexposed control, disease free), 2016 Parker, BDS study, 2018 41.13[0.85; 1.50]9852,710not evaluable Hypospadias Anderka, 2012 Lind, 2013 Pasternak, 2013 Parker, BDS study, 2018 Parker, NBDPS study, 2018 50.90[0.70; 1.15]3,3231,874not evaluable Limb defects Pasternak, 2013 Parker, BDS study, 2018 Parker, NBDPS study, 2018 Huybrechts (Unexposed control), 2018 41.02[0.92; 1.11]8,42590,330not evaluable Urinary malformations Pasternak, 2013 Parker, BDS study, 2018 Huybrechts (Unexposed control), 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 41.23[1.03; 1.46]8,86591,075not evaluable Ano-rectal atresia and stenosis Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 30.79[0.49; 1.27]6711,881not evaluable Atresia or stenosis of other parts of small intestine Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 30.97[0.61; 1.53]3941,880not evaluable Coarctation of aorta Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 30.95[0.69; 1.29]8441,903not evaluable Craniosynostosis Pasternak, 2013 Parker, NBDPS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 31.13[0.95; 1.35]12,7652,512not evaluable Diaphragmatic hernia Pasternak, 2013 Parker, NBDPS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 31.70[1.17; 2.48]8752,394not evaluable Gastroschisis Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 30.89[0.61; 1.29]9591,894not evaluable Hypoplastic left heart (HLH/HLHS) Parker, NBDPS study, 2018 Parker, BDS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 31.49[1.03; 2.17]8381,539not evaluable Pulmonary valve stenosis Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 31.08[0.79; 1.48]1,0251,913not evaluable Severe congenital heart defect Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 20.76[0.63; 0.93]1,88088,851not evaluable Single ventricle Parker, NBDPS study, 2018 Huybrechts (Unexposed control), 2018 20.90[0.34; 2.37]42488,706not evaluable Total anomalous pulm venous return Parker, NBDPS study, 2018 Huybrechts (Unexposed control), 2018 20.84[0.55; 1.30]50288,705not evaluable Abdominal wall defects Pasternak, 2013 Huybrechts (Unexposed control), 2018 20.98[0.90; 1.07]8,81689,679not evaluable Bilateral renal agenesis including Potter syndrome Pasternak, 2013 Parker, BDS study, 2018 21.85[1.13; 3.02]1611,630not evaluable Cardiac septal defects Danielsson, 2014 Zambelli-Weiner (Unexposed control, NOS), 2019 21.57[1.17; 2.12]39,4752,528not evaluable Congenital cataract Pasternak, 2013 Parker, NBDPS study, 2018 20.94[0.46; 1.91]2111,494not evaluable Digestive system anomalies Pasternak, 2013 Huybrechts (Unexposed control), 2018 20.93[0.85; 1.02]9,59889,700not evaluable Eye defects Pasternak, 2013 Huybrechts (Unexposed control), 2018 20.95[0.69; 1.30]77289,700not evaluable Genital anomalies Pasternak, 2013 Huybrechts (Unexposed control), 2018 21.06[0.97; 1.17]7,10089,679not evaluable Limb reduction defects (LRD) Pasternak, 2013 Zambelli-Weiner (Unexposed control, NOS), 2019 21.01[0.39; 2.58]5632,115not evaluable Nervous system anomalies Pasternak, 2013 Huybrechts (Unexposed control), 2018 20.94[0.81; 1.09]3,49689,679not evaluable Oesophageal atresia with or without tracheo-oesophageal fistula Pasternak, 2013 Parker, NBDPS study, 2018 20.71[0.40; 1.28]3641,496not evaluable Patent ductus arterious Huybrechts (Unexposed control), 2018 10.90[0.73; 1.11]1,67588,446not evaluable Respiratory system anomalies Pasternak, 2013 Huybrechts (Unexposed control), 2018 21.13[1.01; 1.27]3,95189,679not evaluable Spina bifida Parker, NBDPS study, 2018 Parker, BDS study, 2018 21.24[0.83; 1.83]461620not evaluable Transposition of the great vessels Parker, NBDPS study, 2018 Parker, BDS study, 2018 20.80[0.52; 1.23]584649not evaluable Anophthalmos/micropthalmos Parker, NBDPS study, 2018 10.90[0.31; 2.65]132257not evaluable Anotia Parker, NBDPS study, 2018 11.10[0.59; 2.06]354263not evaluable Aortic valve atresia/stenosis Parker, NBDPS study, 2018 10.50[0.20; 1.22]272260not evaluable Atresia of bile ducts Parker, NBDPS study, 2018 11.30[0.51; 3.29]101258not evaluable Bladder exstrophy and/or epispadia Pasternak, 2013 11.33[0.05; 32.76]11,233not evaluable Choanal atresia Pasternak, 2013 11.33[0.05; 32.76]11,233not evaluable Congenital constriction bands/amniotic band Parker, NBDPS study, 2018 11.30[0.51; 3.29]155258not evaluable Congenital glaucoma Pasternak, 2013 14.00[0.25; 64.04]21,233not evaluable Congenital hydronephrosis Pasternak, 2013 10.80[0.17; 3.65]121,233not evaluable Congenital skin disorders Pasternak, 2013 10.57[0.03; 11.07]31,233not evaluable Ear malformations Huybrechts (Unexposed control), 2018 11.67[1.17; 2.38]45088,446not evaluable Ear, face and neck anomalies Pasternak, 2013 14.00[0.25; 64.04]21,233not evaluable Ebstein's anomaly Parker, NBDPS study, 2018 11.10[0.39; 3.11]108257not evaluable Hirschsprung's disease Parker, BDS study, 2018 11.20[0.60; 2.40]110385not evaluable Hydrocephaly Parker, NBDPS study, 2018 11.40[0.76; 2.57]254264not evaluable Intestinal malrotation Parker, BDS study, 2018 11.10[0.57; 2.11]125385not evaluable Microcephaly / Small head circumference for gestational age Kerr, 2018 10.99[0.18; 5.53]57428not evaluable Multicystic renal dysplasia Parker, BDS study, 2018 11.40[0.83; 2.37]176394not evaluable Neural Tube Defects Anderka, 2012 10.60[0.21; 1.70]71148not evaluable Omphalocele Parker, NBDPS study, 2018 11.10[0.47; 2.56]187269not evaluable Polydactyly Pasternak, 2013 10.36[0.02; 6.58]51,233not evaluable Pulmonary artery atresia Pasternak, 2013 11.33[0.05; 32.76]11,233not evaluable Pulmonary artery stenosis Pasternak, 2013 11.33[0.05; 32.76]11,233not evaluable Pulmonary valve atresia Parker, NBDPS study, 2018 10.70[0.23; 2.10]144257not evaluable Situs inversus Parker, NBDPS study, 2018 10.70[0.27; 1.81]185257not evaluable Syndactyly Pasternak, 2013 12.67[0.45; 15.99]51,233not evaluable Tetralogy of Fallot Parker, NBDPS study, 2018 10.90[0.57; 1.42]616274not evaluable Growth parameters and prematurity Preterm (< 37 weeks) Pasternak, 2013 Colvin, 2013 Ozdemirci, 2014 Fejzo (Unexposed control, disease free), 2016 41.28[0.76; 2.15]8,5763,213not evaluable Low birth weight (< 2500g) Pasternak, 2013 Colvin, 2013 Ozdemirci, 2014 31.04[0.61; 1.77]7,4512,147not evaluable Small for gestational age (weight) Pasternak, 2013 Colvin, 2013 20.96[0.69; 1.35]50,6642,047not evaluable Maternal consequences Caesarean Colvin, 2013 Shahraki, 2016 21.63[1.28; 2.07]31,113339not evaluable Preeclampsia Colvin, 2013 Ozdemirci, 2014 21.54[0.93; 2.56]4,362351not evaluable Postpartum hemorrhage Colvin, 2013 11.20[0.71; 2.03]8,862251not evaluable Neonatal disorders Low Apgar score (< 7) (at 5 min) Colvin, 2013 Marciniak, 2015 21.89[0.62; 5.75]56735not evaluable Neonatal medical care Colvin, 2013 Shahraki, 2016 21.21[0.94; 1.55]42,510351not evaluable Persistent pulmonary hypertension 0----- Low Apgar score (< 7) (at 1 min) Marciniak, 2015 10.47[0.04; 5.45]335not evaluable Neonatal hypotension Oofuvong, 2018 11.52[0.06; 37.69]1143not evaluable Neonatal tachypnea Oofuvong, 2018 11.27[0.24; 6.70]7143not evaluable Intrauterine deaths Late intrauterine deaths (> 22 weeks) / Stillbirths Einarson (Unexposed control), 2004 Pasternak, 2013 Colvin, 2013 Fejzo (Unexposed control, disease free), 2016 41.11[0.60; 2.05]6793,424not evaluable Early intrauterine deaths (< 22 weeks) / Spontaneous abortions Einarson (Unexposed control), 2004 Pasternak, 2013 Fejzo (Unexposed control, disease free), 2016 30.40[0.32; 0.50]6423,095not evaluable Ectopic pregnancy Fejzo (Unexposed control, disease free), 2016 11.82[0.37; 8.83]91,070not evaluable Elective/induced termination of pregnancy Fejzo (Unexposed control, disease free), 2016 11.10[0.71; 1.70]861,070not evaluable Therapeutic terminations of pregnancy Einarson (Unexposed control), 2004 15.06[0.24; 106.12]2176not evaluable Intrauterine deaths (as a whole or unspecified) Ozdemirci, 2014 10.28[0.01; 6.96]1100not evaluable Neuro-developmental disorders ADHD (Attention deficit hyperactivity disorder): Diagnosis Clements, 2015 11.36[0.95; 1.94]2,243163not evaluable ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk Clements, 2015 11.36[0.95; 1.94]2,243163not evaluable ASD (Autism spectrum disorder): Diagnosis Clements, 2015 11.39[0.97; 2.00]1,377173not evaluable ASD (Autism spectrum disorder): Diagnosis/Risk Clements, 2015 11.39[0.97; 2.00]1,377173not evaluable Neuro-developmental disorders (as a whole) Fejzo, 2015 11.34[0.82; 2.17]138213not evaluable0.0100.01.0

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