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Tofisopam
updated on 02-10-2025
Overall results
Study description
Excluded studies
Table
Graphic
exposition period:
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
Congenital malformations
Adverse outcome
OR 95%CI
I2
k
No. cases
No. exposed
publication bias
ROB
E-value
All congenital malformations (majors, minors, majors and minors, or unspecified)
1.05
[
0.94
, 1.18]
-
1 study
157,170
4,804
not evaluable
ROB
-
Congenital heart defects
1.09
[
0.93
, 1.28]
-
1 study
83,737
4,804
not evaluable
ROB
-
Major congenital malformations
1.05
[
0.94
, 1.18]
-
1 study
157,170
4,804
not evaluable
ROB
-
Ano-rectal atresia and stenosis
-
-
0 study
-
Atresia or stenosis of other parts of small intestine
-
-
0 study
-
Bilateral renal agenesis including Potter syndrome
-
-
0 study
-
Cleft lip with or without cleft palate
-
-
0 study
-
Cleft palate
-
-
0 study
-
Club foot / Talipes equinovarus
-
-
0 study
-
Ear malformations
-
-
0 study
-
Eye defects
-
-
0 study
-
Gastroschisis
-
-
0 study
-
Genital anomalies
-
-
0 study
-
Hydrocephaly
-
-
0 study
-
Hypospadias
-
-
0 study
-
Limb reduction defects (LRD)
-
-
0 study
-
Microcephaly / Small head circumference for gestational age
-
-
0 study
-
Neural Tube Defects
-
-
0 study
-
Oesophageal atresia with or without tracheo-oesophageal fistula
-
-
0 study
-
Polydactyly
-
-
0 study
-
Hide endpoints reported in only one study ...
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absolute risk increase extrapolation
Relative risk
Spontaneous risk
/100
/1,000
/10,000
/100,000
absolute risk increase