metaPreg - Mebendazole during pregnancy

Mebendazole updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.50 [0.68, 3.27]	63%	4 studies	45,490	1,528	not evaluable	ROB	-
Major congenital malformations	1.50 [0.68, 3.27]	63%	4 studies	45,490	1,528	not evaluable	ROB	-
Congenital heart defects	5.10 [0.42, 61.62]	-	1 study	4,479	3	not evaluable	ROB	-
Minor congenital malformations	0.80 [0.48, 1.34]	-	1 study	13,641	1,022	not evaluable	ROB	-
Digestive system anomalies	-	-	0 study					-
Genital anomalies	-	-	0 study					-
Hypospadias	8.60 [0.79, 93.86]	-	1 study	3,038	3	not evaluable	ROB	-
Limb defects	-	-	0 study					-
Nervous system anomalies	-	-	0 study					-
Polydactyly	13.50 [1.20, 151.44]	-	1 study	1,744	3	not evaluable	ROB	26.49 [1.70; .]
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Small for gestational age (weight)	1.00 [0.85, 1.17]	-	1 study	70,203	2,567	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neonatal death (< 28 days of life)	0.80 [0.30, 2.17]	-	1 study	2,060	2,567	not evaluable	ROB	-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Late intrauterine deaths (> 22 weeks) / Stillbirths	0.90 [0.39, 2.06]	-	1 study	2,555	2,567	not evaluable	ROB	-
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	1.25 [0.65, 2.42]	-	1 study	40	192	not evaluable	ROB	-
Ectopic pregnancy	-	-	0 study					-
Elective/induced termination of pregnancy	8.15 [2.40, 27.73]	-	1 study	25	192	not evaluable	ROB	15.79 [4.23; .]
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