metaPreg - Metronidazole (local route only) during pregnancy

Metronidazole (local route only) updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.10 [0.80, 1.51]	-	1 study	22,843	168	not evaluable	ROB	-
Ano-rectal atresia and stenosis	0.88 [0.05, 14.21]	-	1 study	220	98	not evaluable	ROB	-
Cleft lip with or without cleft palate	2.20 [0.60, 8.08]	-	1 study	1,374	104	not evaluable	ROB	-
Cleft palate	0.33 [0.02, 5.35]	-	1 study	582	98	not evaluable	ROB	-
Club foot / Talipes equinovarus	1.60 [0.50, 5.16]	-	1 study	2,424	104	not evaluable	ROB	-
Congenital heart defects	1.00 [0.48, 2.10]	-	1 study	4,479	110	not evaluable	ROB	-
Ear malformations	0.55 [0.03, 8.82]	-	1 study	354	98	not evaluable	ROB	-
Gastroschisis	0.81 [0.05, 13.13]	-	1 study	238	98	not evaluable	ROB	-
Hydrocephaly	10.70 [1.10, 104.29]	-	1 study	314	103	not evaluable	ROB	20.89 [1.43; .]
Hypospadias	0.70 [0.31, 1.57]	-	1 study	3,038	108	not evaluable	ROB	-
Limb reduction defects (LRD)	1.20 [0.18, 8.14]	-	1 study	548	100	not evaluable	ROB	-
Major congenital malformations	1.10 [0.80, 1.51]	-	1 study	22,843	168	not evaluable	ROB	-
Neural Tube Defects	0.30 [0.08, 1.20]	-	1 study	1,202	100	not evaluable	ROB	-
Oesophageal atresia with or without tracheo-oesophageal fistula	7.00 [0.72, 68.48]	-	1 study	217	102	not evaluable	ROB	-
Polydactyly	0.60 [0.18, 1.99]	-	1 study	1,744	101	not evaluable	ROB	-
Bilateral renal agenesis including Potter syndrome	1.87 [0.12, 30.25]	-	1 study	104	98	not evaluable	ROB	-
Microcephaly / Small head circumference for gestational age	1.30 [0.18, 9.42]	-	1 study	109	390	not evaluable	ROB	-
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