Miconazole (local route only) updated on 01-29-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.27 [1.03, 1.58]0%2 studies28,648668not evaluable ROB1.86 [1.20; .]
Cleft lip with or without cleft palate2.43 [0.91, 6.47]40%2 studies1,502530not evaluable ROB-
Congenital heart defects1.11 [0.73, 1.69]0%2 studies6,886543not evaluable ROB-
Major congenital malformations1.27 [1.03, 1.58]0%2 studies28,648668not evaluable ROB1.86 [1.20; .]
Ano-rectal atresia and stenosis8.80 [0.92, 84.25]-1 study220207not evaluable ROB-
Cleft palate1.90 [0.42, 8.55]-1 study582207not evaluable ROB-
Club foot / Talipes equinovarus0.90 [0.42, 1.91]-1 study2,424214not evaluable ROB-
Digestive system anomalies2.05 [0.51, 8.29]-1 study301313not evaluable ROB-
Ear malformations0.26 [0.02, 4.24]-1 study354203not evaluable ROB-
Gastroschisis2.90 [0.31, 27.31]-1 study238207not evaluable ROB-
Hydrocephaly1.60 [0.09, 27.94]-1 study314204not evaluable ROB-
Hypospadias1.00 [0.53, 1.90]-1 study3,038222not evaluable ROB-
Limb defects2.10 [1.12, 3.94]-1 study1,437313not evaluable ROB3.62 [1.48; .]
Limb reduction defects (LRD)0.40 [0.09, 1.88]-1 study548205not evaluable ROB-
Nervous system anomalies1.10 [0.35, 3.45]-1 study792313not evaluable ROB-
Neural Tube Defects1.20 [0.48, 2.99]-1 study1,202212not evaluable ROB-
Oesophageal atresia with or without tracheo-oesophageal fistula1.90 [0.30, 12.22]-1 study217206not evaluable ROB-
Polydactyly6.00 [2.38, 15.10]-1 study1,744224not evaluable ROB11.48 [4.20; .]

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions1.34 [0.99, 1.81]-1 study6,367633not evaluable ROB-

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