Clobazam (Epilepsy) updated on 02-10-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)5.36 [1.56, 18.43]16%4 studies13536not evaluable ROB10.20 [2.50; .]
Major congenital malformations5.36 [1.56, 18.43]16%4 studies13536not evaluable ROB10.20 [2.50; .]
Congenital heart defects1.29 [0.07, 23.31]-1 study914not evaluable ROB-
Digestive system anomalies8.36 [0.33, 214.82]-1 study114not evaluable ROB-
Limb defects13.00 [1.11, 152.71]-1 study314not evaluable ROB25.49 [1.45; .]
Microcephaly / Small head circumference for gestational age0.58 [0.04, 9.54]-1 study69927not evaluable ROB-
Nervous system anomalies147.61 [6.70, 3253.00]-1 study214not evaluable ROB294.72 [12.88; .]
Urinary malformations1.90 [0.10, 35.50]-1 study614not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Intrauterine deaths (as a whole or unspecified)8.54 [0.62, 117.78]-1 study611not evaluable ROB-

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Cognitive developmental disorders/delay (< 3 years old)3.87 [0.96, 15.63]-1 study7not evaluable ROB-
Psychomotor developmental disorders/delay2.65 [0.66, 10.65]-1 study7not evaluable ROB-

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