metaPreg - Clomipramine during pregnancy

Clomipramine updated on 10-20-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.20 [0.94, 1.53]	0%	2 studies	30,630	1,400	not evaluable	ROB	-
Major congenital malformations	1.20 [0.94, 1.53]	0%	2 studies	30,630	1,400	not evaluable	ROB	-
Cardiac septal defects	1.85 [1.24, 2.77]	-	1 study		1,399	not evaluable	ROB	3.10 [1.77; .]
Congenital heart defects	1.49 [1.03, 2.15]	-	1 study		1,399	not evaluable	ROB	2.34 [1.21; .]
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	1.85 [0.87, 3.94]	0%	3 studies	25	14	not evaluable	ROB	-
Elective/induced termination of pregnancy	17.97 [0.34, 938.20]	-	1 study	14	1	not evaluable	ROB	-
Neuro-developmental disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
ASD (Autism spectrum disorder): Diagnosis	1.76 [1.01, 3.06]	-	1 study	369	235	not evaluable	ROB	2.92 [1.13; .]
ASD (Autism spectrum disorder): Diagnosis/Risk	1.76 [1.01, 3.06]	-	1 study	369	235	not evaluable	ROB	2.92 [1.13; .]
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