Cloxazolam / Oxazolam

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Meng a (Controls unexposed, sibling), 2023	population based cohort retrospective	The National Health Insurance (NHI) database that comprises anonymised health insurance claims for visits, procedures, and prescriptions for more than 99% of the population in Taiwan (about 23 million).	The National Birth Certificate Application (BCA) database that includes notably gestational age at birth, birth date of newborns, singleton or multiple pregnancy, birthweight, and birth outcomes.	Siblings. Singletons only. Adjusted for maternal age, sex of the infant, birth year, psychiatric medical conditions, tobacco use, alcohol use, drug abuse, and obstetric comorbidity index scores.
Meng a (Controls unexposed, sick), 2023	population based cohort retrospective	The National Health Insurance (NHI) database that comprises anonymised health insurance claims for visits, procedures, and prescriptions for more than 99% of the population in Taiwan (about 23 million).	The National Birth Certificate Application (BCA) database that includes notably gestational age at birth, birth date of newborns, singleton or multiple pregnancy, birthweight, and birth outcomes.	Singletons only. Propensity score (PS-FSW) to control for maternal age and nationality, sex of the infant and year of birth, indications for use (eg, anxiety, insomnia, depression, schizophrenia, epilepsy, and bipolar disorder), lifestyle factors (obesity, tobacco, alcohol, ...), chronic maternal comorbidities (hypertension, diabetes, ...), medication use, obstetric comorbidity, health-care use.
Meng b, 2023	other	The National Health Insurance (NHI) database that comprises anonymized prescriptions for more than 99% of the population in Taiwan.	The National Health Insurance (NHI) database that comprises anonymized health insurance claims for visits and procedures for more than 99% of the population and the Birth Certificate Application (BCA) database (all live births and stillbirths > 20 gestational weeks or birth weight > 500g).	Controls matched for the birth year and a disease risk score (based on age, psychiatric medical conditions, lifestyle factors (obesity, tobacco, alcohol, drug misuse), chronic comorbidities (diabetes, hypertension, hyperlipidemia, …), medication use, and health care use). Adjusted for the comedication use (antidepressants, opioid analgesics, anticonvulsant, Z-hypnotics, and other anxiolytics).

master protocol