Study Type of data Exposure measurement Outcome assessment Adjustment
Morrow (Piracetam) (Controls exposed to Lamotrigine, sick), 2006 prospective cohort Information was collected at registration and changes of antiepileptic drugs during pregnancy were detected during the follow-up duration by sending a standardised questionnaire to the patient's general practitioner. Other health care practitioners were contacted if identified. Outcome data were collected by sending the patient’s general practitioner a standardised questionnaire for completion during the follow-up duration. Other health care practitioners were contacted if identified. Pregnancy losses with no major malformation are excluded. No adjustment for this group of comparison.
Morrow (Piracetam) (Controls unexposed, sick), 2006 prospective cohort Information was collected at registration and changes of antiepileptic drugs during pregnancy were detected during the follow-up duration by sending a standardised questionnaire to the patient's general practitioner. Other health care practitioners were contacted if identified. Outcome data were collected by sending the patient’s general practitioner a standardised questionnaire for completion during the follow-up duration. Other health care practitioners were contacted if identified. Pregnancy losses with no major malformation are excluded. No adjustment for this group of exposure.

master protocol