- Medication and Pregnancy KB

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Al-Otaibi, 2019	retrospective cohort	All pregnancy data were collected from medical records maintained by the institution.	All pregnancy data were collected from medical records maintained by the institution.	The 2 groups matched regarding demographic data (pretransplant dialysistype, donor type, induction immunosuppression, and pretransplant comorbidities).
Alvaro, 2013	retrospective cohort	Examination of the records of all women recipients of reproductive age who underwent transplantation from 1986 to 2011.	Examination of the records of all women recipients of reproductive age who underwent transplantation from 1986 to 2011.	None
Ichinose, 2018	retrospective cohort	Patients’ medical records were reviewed retrospectively including clinical and laboratory information.	Patients’ medical records were reviewed retrospectively including clinical and laboratory information.	Adjustment by propensity score. Multiple linear or logistic regression analyses were performed to adjust for age at disease onset, history of LN, and comorbidities of APS and further adjust for the post-measured covariates of thrombocytopenia, hypertension, and anemia as potential confounders.
Kim, 2015	prospective cohort	Medical records. Whole blood trough drug concentrations of CNI were examined at eight consecutive time points: from 12 months before delivery to 12 months after.	Pregnancy outcomes were retrospectively collected from medical records. Generally, patients were followed monthly and when additionally needed during pregnancy.	None.
Perales-Puchalt, 2012	retrospective cohort	Patient information was gathered for clinical records, used to obtain the information for the study in a retrospective manner. The treatment protocol of the patients remained unchanged during the study period.	During the pregnancy patients were examined at least monthly. Patient information was gathered for clinical records, used to obtain the information for the study in a retrospective manner. Data on the children were obtained through telephone contact with the families.	None.
Sugawara, 2019	nested case control	Clinical characteristics including history of rheumatic diseases treatment were recorded from medical records.	Data on pregnancy outcomes and maternal complications were collected (Not other specified).	None
Thompson, 2003	retrospective cohort	Review of the case notes detailed doses of immunosuppression and dose changes made during pregnancy, and other medications.	Outcomes of pregnancy, with percentages of live births, miscarriages, therapeutic abortions, ectopic pregnancies and intrauterine deaths, were determined by retrospective review of the case notes.	None
Wielgos, 2012	retrospective cohort	Complete data was obtained for doses and regimens of immunosuppressive medication and maternal/fetal outcomes (Not otherwise specified).	Complete data was obtained for doses and regimens of immunosuppressive medication and maternal/fetal outcomes (Not otherwise specified).	None

master protocol