Barbesaclone (Epilepsy = All indications)

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Battino (Barbexaclone) (Epilepsy), 2024	prospective cohort	Reporting physicians collected information on drug therapy after each trimester.	Abnormalities in the offspring were recorded descriptively by reporting physicians. A committee blinded to type of exposure assessed and categorized these abnormalities. When necessary, the committee solicited additional information from the reporting physicians.	Exclusion of pregnancies exposed to known teratogenic drugs, and those with comorbidities associated with teratogenic risks. No adjustment for this group of comparison.
Canger (Barbesaclone), 1999	prospective cohort	The patients received monthly obstetric and neurologic examinations, and antiepileptic drug blood levels were tested monthly.	At the time of delivery the infants underwent a standardized examination by a pediatrician, and a more detailed clinical examination on day 5 in San Paolo Hospital only and during the first months in other hospitals (if so medical records were also acquired).	None.