Dimethyl fumarate

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Gold, 2015	retrospective cohort	Clinical studies with administration of DMF. The study treatment was discontinued immediately in the event of pregnancy.	Not specified.	None
Nguyen (control exposed to IFN), 2019	prospective cohort	Data in the MSBase registry, including prospective pregnancy data, is entered in real time or near real time, as part of routine clinical visits. Information collected included: disease-modifying therapies exposure before and during pregnancy.	Data in the MSBase registry, including prospective pregnancy data, is entered in real time or near real time, as part of routine clinical visits. Information collected included pregnancy outcomes.	None
Nguyen (control unexposed, sick), 2019	prospective cohort	Data in the MSBase registry, including prospective pregnancy data, is entered in real time or near real time, as part of routine clinical visits. Information collected included: disease-modifying therapies exposure before and during pregnancy.	Data in the MSBase registry, including prospective pregnancy data, is entered in real time or near real time, as part of routine clinical visits. Information collected included pregnancy outcomes.	None