Anakinra

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
De Lorenzo (Controls unexposed, disease free), 2020	Italy 2009 - 2017	Mothers who attended the Clinic.	Children born to mothers with autoimmune diseases on Anakinra therapy during pregnancy. (This is a subgroup of exposure among the whole exposed group considered in the study).	unexposed, disease free Children born to healthy mothers.	3 / 36
De Lorenzo (Controls unexposed, sick), 2020	Italy 2009 - 2017	Mothers who attended the Clinic.	Children born to mothers with autoimmune diseases on Anakinra therapy during pregnancy. (This is a subgroup of exposure among the whole exposed group considered in the study).	unexposed, sick Children born to mothers with autoimmune diseases not treated with Biologic disease-modifying anti-rheumatic drugs (bDMARDs).	3 / 32	Unexposed: 13 of 32 neonates were born to mothers under no immunosuppressive, 15 to HCQ, 1 to AZA and 3 to both AZA and HCQ.

Study	Country Study period	Case	Control	Sample size	Rmk

3 studies, not fulfilled eligibility criteria, were excluded. See excluded tab for the list of these studies and reason of exclusion.