Ziprasidone - Medication and Pregnancy KB

Ziprasidone

Exposed non-exposed studies (cohort)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Huybrechts (Controls unexposed, NOS), 2023	Denmark, Finland, Iceland, Norway, Sweden and USA. 1996 - 2018	All pregnancies resulting in singleton live-born infants (for Nordic cohorts) and publicly insured mothers linked to their live-born infants (for USA).	Pregnancies with 1 or more prescriptions of Ziprasidone during the first trimester, the period for organogenesis.	unexposed (general population or NOS) Pregnancies who did not fill any antipsychotic prescriptions during the 3 months prior to pregnancy until the end of the first trimester.	-9 / 6455324	Overlapping: Data of Huybrechts 2016 totally included in this larger study. Number of Ziprasidone exposures suppressed due to country-/data-specific small cell suppression policies.
Huybrechts (Controls unexposed, sick), 2023	Denmark, Finland, Iceland, Norway, Sweden and USA. 1996 - 2018	All pregnancies resulting in singleton live-born infants (for Nordic cohorts) and publicly insured mothers linked to their live-born infants (for USA).	Pregnancies with 1 or more prescriptions of Ziprasidone during the first trimester, the period for organogenesis.	unexposed, sick Pregnancies in women with mental health condition, who did not fill any antipsychotic prescriptions during the 3 months prior to pregnancy until the end of the first trimester.	-9 / 318731	Overlapping: Data of Huybrechts 2016 totally included in this larger study. Number of Ziprasidone exposures suppressed due to country-/data-specific small cell suppression policies.
Park, 2018	USA 2000 - 2010	Women who during the 3 months before their last menstrual period filled a prescription for one of the five most frequently used atypical antipsychotics: aripiprazole, olanzapine, quetiapine, risperidone, or ziprasidone.	Pregnant women who had two or more prescriptions dispensed during the first 140 days of their pregnancy for Ziprasidone (also received before pregnancy). Exclusion if more than 1 studied antipsychotic. (This is a subgroup of exposure among the whole exposed group considered in the study).	unexposed, sick Pregnant women who had no prescriptions dispensed for an anti- psychotic medication during the first 140 days of pregnancy were classified as “discontinuers.”	140 / 431	Primary analyses performed individually for each substance (aripiprazole, olanzapine, quetiapine, risperidone, or ziprasidone).
Sorensen, 2015	Denmark 1997 - 2008	Pregnancies registered in the nationwide Danish registries from 1997 to 2008 (N = 1,005,319)	Any prescription of Ziprasidone redeemed by the pregnant women during the exposure window, and recorded in the Danish National Prescription Register. (This is a subgroup of exposure among the whole exposed group considered in the study).	unexposed (general population or NOS) Unexposed women were defined as pregnant women who did not redeem any prescription of antipsychotic medications during the exposure window.	41 / 841183	Primary analyses performed on antipsychotics versus unexposed. Authors also analysed each antipsychotic (typical and atypical) substance separately.

Case-control studies (cohort)

Study	Country Study period	Case	Control	Sample size	Rmk

Warning! There are no case-control studies available for this drug.

1 study, not fulfilled eligibility criteria, were excluded. See excluded tab for the list of these studies and reason of exclusion.

master protocol