Exposed non-exposed studies (cohort)

Study Country
Study period
Population source Exposure definition Non-exposure definition Sample size Rmk
Choi, 2023 South Korea
2008 - 2019
All pregnancies in women < 44 years old resulting in live births during the study period. Pregnant women that filled a prescription for Pantoprazole between the start of pregnancy and the 245th day of gestation. unexposed, sick
Pregnant women without exposure to proton pump inhibitors (PPIs) from 90 days before pregnancy to the delivery date.
6180 / 2121323 Unexposed group adjusted with propensity-score, made by stratification, notably concerning the indications => considered as unexposed sick (mathematical deformation of total population). In South Korea, PPIs only available with a prescription.
Diav-Citrin, 2005 Israel, Germany, Netherlands, Italy, France, Greece and Finland.
1992 - 2001
Pregnant women who or whose physician/midwife contacted one of eight Teratology Information Services (TISes). Pregnancies with exposure to pantoprazole (This is a subgroup of exposure among the whole exposed group considered in the study ). unexposed (general population or NOS)
Group of women who had been counselled during pregnancy in regard to exposures known to be nonteratogenic from seven of the eight participating centres.
53 / 868
Pasternak, 2010 Denmark
1996 - 2008
A cohort of all live-born infants in Denmark for the study period. Infants born to women who were exposed to pantoprazole (any filling of pantoprazole prescription at any time during the period from 4 weeks before conception through the end of the first trimester) (This is a subgroup of exposure among the whole exposed group considered in the study). unexposed (general population or NOS)
Infants born to women not exposed to PPIs (all the women who were not exposed at any time during their pregnancy).
549 / 832031

Case-control studies (cohort)

Study Country
Study period
Case Control Sample size Rmk

master protocol