Tenofovir (local routes)

Exposed non-exposed studies (cohort)

Study Country
Study period
Population source Exposure definition Non-exposure definition Sample size Rmk
Sibeko (vaginal gel), 2011 South Africa
Not specified.
HIV uninfected women between the ages of 18 and 40 were eligibly enrolled at one rural (Vulindlela) and one urban (eThekwini) clinic. Women randomly assigned in tenofovir gel arm within 30 days of the screening visit and that become pregnant. unexposed, sick
Women randomly assigned in placebo arm within 30 days of the screening visit and that become pregnant.
22 / 31 Participants testing positive for pregnancy continued with monthly follow-up visits but study product was temporarily withheld.

Case-control studies (cohort)

Study Country
Study period
Case Control Sample size Rmk

master protocol