Desvenlafaxine

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Marks, 2021	USA 2010 - 2019	Women who received at least one antidepressant prescription 3 months prior to conception through delivery.	Pregnant women with one (or more) prescription of Desvenlafaxine written during the time period studied. (This is a subgroup of exposure among the whole exposed group considered in the study).	exposed to other treatment, sick Pregnant women with one (or more) prescription of Bupropion written during the time period studied.	16 / 406	'252 women (6.8%) prescribed >1 antidepressant'=> considered as monotherapy.

Study	Country Study period	Case	Control	Sample size	Rmk
Anderson, 2020	USA 1997 - 2011	The case infants were infants born alive or died at 20 SG or more and who had received a diagnosis of at least one selected birth defect.	The controls were live-born infants with no major birth defects who were randomly selected from hospital or state birth-certificate records from the same geographic areas.	30630 / 11478	'Infants with recognized or strongly suspected chromosomal abnormalities or single-gene conditions were excluded from the study.'