Amlodipine (versus unexposed) - Medication and Pregnancy KB

Amlodipine (versus unexposed)

Exposed non-exposed studies (cohort)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Ishikawa (Controls unexposed, disease free), 2023	Japan 2010 - 2019	Pregnant women with chronic hypertension	Pregnant women with chronic hypertension and prescribed Amlodipine in the first trimester.	unexposed, disease free Pregnant women without hypertensive disorders in the first trimester.	44 / 74213
Ishikawa (Controls unexposed, sick), 2023	Japan 2010 - 2019	Pregnant women with chronic hypertension	Pregnant women with chronic hypertension and prescribed Amlodipine in the first trimester.	unexposed, sick Pregnant women chronic hypertension but no first-trimester antihypertensive prescriptions.	44 / 1007
Mito, 2019	Japan 2008 - 2016	Pregnant women with chronic hypertension (systolic blood pressure ≥140 mm Hg or a diastolic blood pressure ≥90 mm Hg before pregnancy or before 20 weeks' gestation) whose deliveries resulted in live births.	Chronic hypertensive pregnant women who received Amlodipine, a calcium channel blocker during the first trimester (from estimated conception to 11 weeks and 6 days’ gestation).	unexposed, sick Chronic hypertensive pregnant women who did not receive any antihypertensive drugs.	48 / 129	Data versus Group O (pregnancies exposed to antihypertensives other than amlodipine (including other calcium channel blockers)) cannot be used, because calcium channel blockers in both groups.
Weber-Schoendorfer, 2008	Finland, France, Germany, Israel, Italy, the Netherlands. 1986 - 2003	Pregnant women who or whose physician contacted a Teratology Information Service (TIS) in regard to exposure to chemicals or drugs during pregnancy.	Pregnant women with first- trimester exposure to Amlodipine.	unexposed (general population or NOS) Pregnant women who had been counseled during pregnancy about exposures known to be non-teratogenic.	38 / 806

Case-control studies (cohort)

Study	Country Study period	Case	Control	Sample size	Rmk

Warning! There are no case-control studies available for this drug.

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