Pindolol (versus unexposed)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Rosenfeld, 1986	Israel Not specified.	Consecutive pregnant hypertensive (a systolic blood pressure of 150 mmHg or more or a diastolic pressure of 90 mmHg or more) patients of 36 wk or less, who were routinely referred to the High-Risk Clinics for Hypertensive Pregnant Women.	Hypertensive pregnant patients randomly allocated to the group treated with hydralazine (25 mg b.i.d.) combined with pindolol (5 mg b.i.d).	unexposed, sick Hypertensive pregnant patients randomly allocated to the group treated with hydralazine only (25 mg b.i.d. in the monotherapy).	23 / 21	Chronic hypertension in 11/23 pregnancies exposed to Pindolol and in 10/21 of other pregnancies.

Study	Country Study period	Case	Control	Sample size	Rmk
Medveczky, 2004	Hungary 1980 - 1996	Newborn infants (including infant deaths and usual stillborn fetuses) with Neural tube defects with non-syndromic (i.e. isolated anencephaly, spina bifida aperta/cystica, encephalocele).	Newborn infants (including infant deaths and usual stillborn fetuses) without congenital abnormalities.	1202 / 38151	Study design completed with other studies published on the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA).