Topiramate (Epilepsy)

Study Reference
Alsfouk (Topiramate) (Controls exposed to Lamotrigine, sick), 2021

Alsfouk, B.A. Antiseizure medications use during pregnancy and congenital malformations: A retrospective study in Saudi Arabia Saudi Pharm. J. 2021; 29:939-.

Alsfouk (Topiramate) (Controls unexposed, sick), 2021

Alsfouk, B.A. Antiseizure medications use during pregnancy and congenital malformations: A retrospective study in Saudi Arabia Saudi Pharm. J. 2021; 29:939-.

AlSheikh (Topiramate) (Controls exposed to Lamotrigine, sick), 2020

AlSheikh Prevalence of epilepsy in Saudi pregnant women and possible effects of anti-epileptic drugs on pregnancy outcomes. Neurosciences (Riyadh) 2020; 25:32-37

AlSheikh (Topiramate) (Controls unexposed, sick), 2020

AlSheikh Prevalence of epilepsy in Saudi pregnant women and possible effects of anti-epileptic drugs on pregnancy outcomes. Neurosciences (Riyadh) 2020; 25:32-37

Arkilo (Topiramate), 2015

Arkilo D Pregnancy and neurodevelopmental outcomes with in-utero antiepileptic agent exposure. A pilot study. Eur J Paediatr Neurol 2015;19:37-40

Babic (Topiramate), 2014

Babic Postnatal concerns in children born to women with juvenile myoclonic epilepsy. In: European Congress on Epileptology. vol. 55. Stockholm: Epilepsia; 2014: 128

Battino, 2024

Battino Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy. JAMA Neurol 2024; 81:481-489

Tomson Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol 2018; 17:530-538

Tomson T Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011;10:609-17

Bjørk (Topiramate) (Controls exposed to Lamotrigine, sick), 2022

Bjørk Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. JAMA Neurol 2022; :

Bjørk (Topiramate) (Controls exposed to Lamotrigine, sick), 2018

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Bjørk (Topiramate) (Controls unexposed NOS), 2022

Bjørk Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. JAMA Neurol 2022; :

Bjørk (Topiramate) (Controls unexposed, disease free), 2018

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Bjørk (Topiramate) (Controls unexposed, sick), 2022

Bjørk Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. JAMA Neurol 2022; :

Bjørk (Topiramate) (Controls unexposed, sick), 2018

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Bromley (Topiramate), 2016

Bromley RL Cognition in school-age children exposed to levetiracetam, topiramate, or sodium valproate. Neurology 2016;87:1943-1953

Christensen (Topiramate) (Epilepsy) (Controls exposed to LTG), 2024

Christensen Prenatal exposure to antiseizure medications and fetal growth: a population-based cohort study from the Nordic countries. Lancet Reg Health Eur 2024; 38:100849

Dreier Prenatal exposure to antiseizure medication and intrauterine growth restriction in offspring of women with epilepsy Epilepsia 2021; 62(S3):3-364.

Christensen (Topiramate) (Epilepsy) (Controls unexposed, general population), 2024

Christensen Prenatal exposure to antiseizure medications and fetal growth: a population-based cohort study from the Nordic countries. Lancet Reg Health Eur 2024; 38:100849

Dreier Prenatal exposure to antiseizure medication and intrauterine growth restriction in offspring of women with epilepsy Epilepsia 2021; 62(S3):3-364.

Cohen (Topiramate) (Controls exposed to Lamotrigine, sick), 2019

Cohen Anticonvulsant Mood Stabilizer and Lithium Use and Risk of Adverse Pregnancy Outcomes. J Clin Psychiatry 2019; 80:

Cohen (Topiramate) (Controls unexposed NOS), 2019

Cohen Anticonvulsant Mood Stabilizer and Lithium Use and Risk of Adverse Pregnancy Outcomes. J Clin Psychiatry 2019; 80:

Dreier (Topiramate) (Epilepsy) (Controls exposed to LTG), 2023

Dreier Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders. JAMA Neurol 2023; 80:568-577

Dreier (Topiramate) (Epilepsy) (Controls unexposed, sick), 2023

Dreier Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders. JAMA Neurol 2023; 80:568-577

Hao (Controls exposed to LTG), 2025

Hao Seizure control and pregnancy outcomes in Chinese women with epilepsy: A prospective multicenter cohort study. Epilepsia 2025; :

Hao (Controls unexposed, sick), 2025

Hao Seizure control and pregnancy outcomes in Chinese women with epilepsy: A prospective multicenter cohort study. Epilepsia 2025; :

Hernandez-Diaz, 2024

Hernandez-Diaz Risk of Autism after Prenatal Topiramate, Valproate, or Lamotrigine Exposure. N Engl J Med 2024; 390:1069-1079

Hernández-Díaz (Topiramate), 2012

Hernández-Díaz Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012;78:1692-9

Hernández-Díaz (Topiramate), 2017

Hernández-Díaz S Fetal growth and premature delivery in pregnant women on antiepileptic drugs. Ann Neurol 2017;82:457-465

Husebye (Topiramate) (Controls exposed to Lamotrigine, sick), 2020

Husebye Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study. Eur J Neurol 2020; 27:667-675

Husebye (Topiramate) (Controls unexposed, disease free), 2020

Husebye Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study. Eur J Neurol 2020; 27:667-675

Husebye (Topiramate) (Controls unexposed, sick), 2020

Husebye Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study. Eur J Neurol 2020; 27:667-675

Li (Topiramate) (Controls exposed to LTG), 2023

He Pregnancy outcome in women with epilepsy in Western China: A prospective hospital based study. Epilepsy Behav 2017; 74:10-14

Li Pregnancy characteristics and adverse outcomes in offspring of women with epilepsy: a prospective registry study from Mainland China. Front Neurol 2023; 14:1195003

Li (Topiramate) (Controls unexposed, sick), 2023

He Pregnancy outcome in women with epilepsy in Western China: A prospective hospital based study. Epilepsy Behav 2017; 74:10-14

Li Pregnancy characteristics and adverse outcomes in offspring of women with epilepsy: a prospective registry study from Mainland China. Front Neurol 2023; 14:1195003

Madley-Dowd_SE (Topiramate) (Controls exposed to LTG), 2024

Madley-Dowd Antiseizure medication use during pregnancy and children's neurodevelopmental outcomes. Nat Commun 2024; 15:9640

Madley-Dowd_SE (Topiramate) (Controls unexposed, sick), 2024

Madley-Dowd Antiseizure medication use during pregnancy and children's neurodevelopmental outcomes. Nat Commun 2024; 15:9640

Madley-Dowd_UK (Topiramate) (Controls exposed to LTG) (Epilepsy), 2024

Madley-Dowd Antiseizure medication use during pregnancy and children's neurodevelopmental outcomes. Nat Commun 2024; 15:9640

Madley-Dowd_UK (Topiramate) (Controls unexposed, sick) (Epilepsy), 2024

Madley-Dowd Antiseizure medication use during pregnancy and children's neurodevelopmental outcomes. Nat Commun 2024; 15:9640

Mawer (Topiramate) (Controls exposed to Lamotrigine, sick), 2010

Kini Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero.,Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero. Eur J Med Genet ; 50:411-20

Mawer G Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study. Seizure 2010;19:112-9

Mawer (Topiramate) (Controls unexposed, disease free), 2010

Kini Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero.,Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero. Eur J Med Genet ; 50:411-20

Mawer G Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study. Seizure 2010;19:112-9

Mawer (Topiramate) (Controls unexposed, sick), 2010

Kini Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero.,Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero. Eur J Med Genet ; 50:411-20

Mawer G Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study. Seizure 2010;19:112-9

Meador (Topiramate) (Controls exposed to Lamotrigine, sick), 2021

Meador Two-Year-Old Cognitive Outcomes in Children of Pregnant Women With Epilepsy in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study. JAMA Neurol 2021; 78:927-936

Meador (Topiramate) (Controls exposed to Lamotrigine, sick), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

Meador (Topiramate) (Controls unexposed, disease free), 2021

Meador Two-Year-Old Cognitive Outcomes in Children of Pregnant Women With Epilepsy in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study. JAMA Neurol 2021; 78:927-936

Meador (Topiramate) (Controls unexposed, disease free), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

Meador (Topiramate) (Controls unexposed, sick), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

Morrow (Topiramate) (Controls exposed to Lamotrigine, sick), 2006

Campbell E Recurrence risk of congenital malformations in infants exposed to antiepileptic drugs in utero. Epilepsia 2013;54:165-71

Morrow J Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193-8

Morrow (Topiramate) (Controls unexposed, sick), 2006

Morrow J Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193-8

Nadebaum (Topiramate), 2011

Nadebaum Language skills of school-aged children prenatally exposed to antiepileptic drugs. Neurology 2011; 76:719-26

Ornoy (Topiramate), 2008

Ornoy The outcome of pregnancy following topiramate treatment: a study on 52 pregnancies.,The outcome of pregnancy following topiramate treatment: a study on 52 pregnancies. Reprod. Toxicol. 2008; 25:388-9

Razaz (Topiramate), 2024

Razaz Risk of Perinatal and Maternal Morbidity and Mortality Among Pregnant Women With Epilepsy. JAMA Neurol 2024; 81:985-995

Razaz (Topiramate) (Controls exposed to Lamotrigine, sick), 2017

Razaz Association Between Pregnancy and Perinatal Outcomes Among Women With Epilepsy. JAMA Neurol 2017; 74:983-991

Razaz (Topiramate) (Controls unexposed, disease free), 2017

Razaz Association Between Pregnancy and Perinatal Outcomes Among Women With Epilepsy. JAMA Neurol 2017; 74:983-991

Razaz (Topiramate) (Controls unexposed, sick), 2017

Razaz Association Between Pregnancy and Perinatal Outcomes Among Women With Epilepsy. JAMA Neurol 2017; 74:983-991

Thomas (Topiramate) (Controls exposed to Lamotrigine, sick), 2021

Keni Teratogenicity of antiepileptic dual therapy: Dose-dependent, drug-specific, or both? Neurology 2018; 90:e790-e796

Thomas Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India. Epilepsia 2017; 58:274-281

Thomas Malformation risk of new anti-epileptic drugs in women with epilepsy; observational data from the Kerala registry of epilepsy and pregnancy (KREP). Seizure 2021; 93:127-132

Thomas (Topiramate) (Controls unexposed, disease free), 2021

Thomas Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India. Epilepsia 2017; 58:274-281

Thomas (Topiramate) (Controls unexposed, sick), 2021

Thomas Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India. Epilepsia 2017; 58:274-281

Thomas Malformation risk of new anti-epileptic drugs in women with epilepsy; observational data from the Kerala registry of epilepsy and pregnancy (KREP). Seizure 2021; 93:127-132

Thomas b (Controls exposed to LTG), 2022

Thomas, S.V. Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsy Epileptic Disord. 2022; 24:531-.

Thomas b (Controls unexposed, sick), 2022

Thomas, S.V. Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsy Epileptic Disord. 2022; 24:531-.

Tomson (Topiramate), 2018

Tomson Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011; 10:609-17

Tomson Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol 2018; 17:530-538

Trivedi (Topiramate) (Controls exposed to Lamotrigine, sick), 2018

Trivedi Spontaneous fetal loss in women with epilepsy: prospective data from pregnancy registry in India. Epilepsy Res 2018; 146:50-53

Trivedi (Topiramate) (Controls unexposed, sick), 2018

Trivedi Spontaneous fetal loss in women with epilepsy: prospective data from pregnancy registry in India. Epilepsy Res 2018; 146:50-53

Vajda (Topiramate) (Controls exposed to Lamotrigine, sick), 2013

Vajda Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11

Vajda Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurol. Scand. 2013; 128:228-34

Vajda (Topiramate) (Controls unexposed, sick), 2013

Vajda Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurol Scand 2013; 128:228-34

Vajda Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11

Vajda a (Topiramate) (Controls exposed to LTG), 2024

Vajda Pregnancy, antiseizure medications and unexplained intrauterine foetal death. Epilepsy Behav 2024; 153:109724

Vajda Anti-epileptic drug exposure and risk of foetal death in utero. Acta Neurol Scand 2018; 137:20-23

Vajda a (Topiramate) (Controls unexposed sick), 2024

Vajda Pregnancy, antiseizure medications and unexplained intrauterine foetal death. Epilepsy Behav 2024; 153:109724

Vajda Anti-epileptic drug exposure and risk of foetal death in utero. Acta Neurol Scand 2018; 137:20-23

Vajda b (Topiramate) (Epilepsy) (Controls exposed to Lamotrigine, sick), 2024

Vajda Teratogenicity of the newer antiepileptic drugs--the Australian experience. J Clin Neurosci 2012; 19:57-9

Vajda Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. Seizure 2010; 19:558-61

Vajda The prescribing of antiepileptic drugs for pregnant Australian women. Aust N Z J Obstet Gynaecol 2012; 52:49-53

Vajda Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurol Scand 2013; 128:228-34

Vajda The teratogenic risk of antiepileptic drug polytherapy. Epilepsia 2010; 51:805-10

Vajda The Australian Register of Antiepileptic Drugs in Pregnancy: the first 1002 pregnancies. Aust N Z J Obstet Gynaecol 2007; 47:468-74

Vajda Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11

Vajda The teratogenicity of the newer antiepileptic drugs - an update. Acta Neurol Scand 2014; 130:234-8

Vajda The teratogenesis risk associated with antiseizure medication duotherapy in women with epilepsy. Epilepsy Res 2024; 200:107316

Vajda b (Topiramate) (Epilepsy) (Controls unexposed, sick), 2024

Vajda Teratogenicity of the newer antiepileptic drugs--the Australian experience. J Clin Neurosci 2012; 19:57-9

Vajda Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. Seizure 2010; 19:558-61

Vajda The prescribing of antiepileptic drugs for pregnant Australian women. Aust N Z J Obstet Gynaecol 2012; 52:49-53

Vajda Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurol Scand 2013; 128:228-34

Vajda The teratogenic risk of antiepileptic drug polytherapy. Epilepsia 2010; 51:805-10

Vajda The Australian Register of Antiepileptic Drugs in Pregnancy: the first 1002 pregnancies. Aust N Z J Obstet Gynaecol 2007; 47:468-74

Vajda Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11

Vajda The teratogenicity of the newer antiepileptic drugs - an update. Acta Neurol Scand 2014; 130:234-8

Vajda The teratogenesis risk associated with antiseizure medication duotherapy in women with epilepsy. Epilepsy Res 2024; 200:107316

Veiby (Topiramate) (Controls exposed to Lamotrigine, sick), 2014

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J. Neurol. 2014; 261:579-88

Veiby (Topiramate) (Controls unexposed, disease free), 2014

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J. Neurol. 2014; 261:579-88

Veiby (Topiramate) (Controls unexposed, sick), 2014

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J. Neurol. 2014; 261:579-88

Wood (Topiramate), 2015

Wood Prospective assessment of autism traits in children exposed to antiepileptic drugs during pregnancy. Epilepsia 2015; 56:1047-55