| Study | Reference | 
            
            
                | Anderka, 2012 | Anderka Medications used to treat nausea and vomiting of pregnancy and the risk of selected birth defects.  Birth Defects Res A Clin Mol Teratol 2012; 94:22-30  | 
            
            
                | Andersen (Controls exposed to clarithromycin), 2013 | Andersen Clarithromycin in early pregnancy and the risk of miscarriage and malformation: a register based nationwide cohort study.  PLoS ONE 2013; 8:e53327  | 
            
            
                | Andersen (Controls exposed to other treatment, sick), 2012 | Andersen Prenatal exposure to acid-suppressive drugs and the risk of childhood asthma: a population-based Danish cohort study.  Aliment. Pharmacol. Ther. 2012; 35:1190-8  | 
            
            
                | Andersen (Controls unexposed NOS), 2012 | Andersen Prenatal exposure to acid-suppressive drugs and the risk of childhood asthma: a population-based Danish cohort study.  Aliment. Pharmacol. Ther. 2012; 35:1190-8  | 
            
            
                | Andersen (Controls unexposed, NOS), 2013 | Andersen Clarithromycin in early pregnancy and the risk of miscarriage and malformation: a register based nationwide cohort study.  PLoS ONE 2013; 8:e53327  | 
            
            
                | Bànhidy - Omeprazole, 2011 | Bànhidy Peptic ulcer disease with related drug treatment in pregnant women and congenital abnormalities in their offspring.  Congenit Anom (Kyoto) 2011; 51:26-33  | 
            
            
                | Breddels, 2022 | Breddels Population-based cohort study: proton pump inhibitor use during pregnancy in Sweden and the risk of maternal and neonatal adverse events.  BMC Med 2022; 20:492  | 
            
            
                | Cea  Soriano, 2016 | Cea Soriano Exposure to acid-suppressing drugs during pregnancy and the risk of asthma in childhood: an observational cohort study.  Aliment. Pharmacol. Ther. 2016; 43:427-37  Cea Soriano Association between exposure to acidsuppressing drugs during pregnancy and asthma in childhood  Pharmacoepidemiol. Drug Saf. 2015; 24:242-.  | 
            
            
                | Choi (Controls exposed to other treatment, sick), 2021 | Choi Exploration of Proton Pump Inhibitors Use During Pregnancy and Preeclampsia.  JAMA Netw Open 2021; 4:e2124339  | 
            
            
                | Choi (Controls unexposed NOS), 2021 | Choi Exploration of Proton Pump Inhibitors Use During Pregnancy and Preeclampsia.  JAMA Netw Open 2021; 4:e2124339  | 
            
            
                | Choi a (Controls unexposed, sibling), 2023 | Choi Association Between Proton Pump Inhibitor Use During Early Pregnancy and Risk of Congenital Malformations.  JAMA Netw Open 2023; 6:e2250366  | 
            
            
                | Choi a (Controls unexposed, sick), 2023 | Choi Association Between Proton Pump Inhibitor Use During Early Pregnancy and Risk of Congenital Malformations.  JAMA Netw Open 2023; 6:e2250366  | 
            
            
                | Choi b (Controls unexposed, sibling), 2023 | Choi Maternal Proton Pump Inhibitor Use During Pregnancy and Risk of Low Birth Weight in Offspring in Korea, 2008-2019.  JAMA Netw Open 2023; 6:e237962  | 
            
            
                | Choi b (Controls unexposed, sick), 2023 | Choi Maternal Proton Pump Inhibitor Use During Pregnancy and Risk of Low Birth Weight in Offspring in Korea, 2008-2019.  JAMA Netw Open 2023; 6:e237962  | 
            
            
                | Cluver - Esomeprazole, 2018 | Cluver Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial.  Am. J. Obstet. Gynecol. 2018; 219:388.e1-388.e17  | 
            
            
                | Colvin, 2011 | Colvin Dispensing patterns and pregnancy outcomes in women dispensed proton pump inhibitors during pregnancy  Pharmacoepidemiol Drug Saf. 2011;20:S45-S46  | 
            
            
                | Dehlink (Controls exposed to other treatment, sick), 2009 | Dehlink First evidence of a possible association between gastric acid suppression during pregnancy and childhood asthma: a population-based register study.  Clin. Exp. Allergy 2009; 39:246-53  | 
            
            
                | Dehlink (Controls unexposed NOS), 2009 | Dehlink First evidence of a possible association between gastric acid suppression during pregnancy and childhood asthma: a population-based register study.  Clin. Exp. Allergy 2009; 39:246-53  | 
            
            
                | Diav-Citrin, 2005 | Diav-Citrin The safety of proton pump inhibitors in pregnancy: a multicentre prospective controlled study.  Aliment. Pharmacol. Ther. 2005; 21:269-75  | 
            
            
                | Fejzo - Lansoprazole, 2015 | Fejzo MS Neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum.  Eur J Obstet Gynecol Reprod Biol 2015;189:79-84  | 
            
            
                | Fejzo - Lansoprazole, 2013 | Fejzo Antihistamines and other prognostic factors for adverse outcome in hyperemesis gravidarum.  Eur. J. Obstet. Gynecol. Reprod. Biol. 2013; 170:71-6  | 
            
            
                | Hak, 2013 | Hak Use of acid-suppressive drugs in pregnancy and the risk of childhood asthma: bidirectional crossover study using the general practice research database.  Drug Saf 2013; 36:1097-104  | 
            
            
                | Källèn, 1998 | Källén Delivery outcome after the use of acid-suppressing drugs in early pregnancy with special reference to omeprazole.  Br J Obstet Gynaecol 1998; 105:877-81  | 
            
            
                | Källén, 2003 | Källén Maternal drug use in early pregnancy and infant cardiovascular defect  Reproductive Toxicology 2003; 17:255-.  | 
            
            
                | Källén - Omeprazole, 2001 | Källén Use of omeprazole during pregnancy--no hazard demonstrated in 955 infants exposed during pregnancy.  Eur. J. Obstet. Gynecol. Reprod. Biol. 2001; 96:63-8  | 
            
            
                | Kerr, 2018 | Kerr Risk factors for congenital microcephaly in the pre-Zika era.  Birth Defects Res 2019; 111:96-118  | 
            
            
                | Lalkin - Omeprazole (Controls exposed to other treatment, sick), 1998 | Lalkin The safety of omeprazole during pregnancy: a multicenter prospective controlled study.  Am. J. Obstet. Gynecol. 1998; 179:727-30  | 
            
            
                | Lalkin - Omeprazole (Controls unexposed NOS), 1998 | Lalkin The safety of omeprazole during pregnancy: a multicenter prospective controlled study.  Am. J. Obstet. Gynecol. 1998; 179:727-30  | 
            
            
                | Lind, 2013 | Lind Maternal medication and herbal use and risk for hypospadias: data from the National Birth Defects Prevention Study, 1997-2007.  Pharmacoepidemiol Drug Saf 2013; 22:783-93  | 
            
            
                | Malaeb, 2021 | Malaeb Preconception exposure to over-the-counter medications and antibiotics and the risk of childhood asthma in Lebanon: A cross-sectional study.  Allergol Immunopathol (Madr) 2021; 49:104-112  | 
            
            
                | Matok, 2012 | Matok The safety of fetal exposure to proton-pump inhibitors during pregnancy.  Dig. Dis. Sci. 2012; 57:699-705  | 
            
            
                | Moretti, 2002 | Moretti (cited by Nikfar 2002) Use of proton pump inhibitors during pregnancy and rates of major malformations (Personal communication).  2002   | 
            
            
                | Mulder, 2014 | Mulder Prenatal exposure to acid-suppressive drugs and the risk of allergic diseases in the offspring: a cohort study.  Clin. Exp. Allergy 2014; 44:261-9  | 
            
            
                | Munch, 2014 | Munch Risk factors for congenital hydrocephalus: a nationwide, register-based, cohort study.  J. Neurol. Neurosurg. Psychiatry 2014; 85:1253-9  | 
            
            
                | Nielsen, 1999 | Nielsen The safety of proton pump inhibitors in pregnancy.  Aliment. Pharmacol. Ther. 1999; 13:1085-9  | 
            
            
                | Noh, 2023 | Noh Prenatal and Infant Exposure to Acid-Suppressive Medications and Risk of Allergic Diseases in Children.  JAMA Pediatr 2023; 177:267-277  | 
            
            
                | Pasternak, 2010 | Pasternak Use of proton-pump inhibitors in early pregnancy and the risk of birth defects.  N. Engl. J. Med. 2010; 363:2114-23  | 
            
            
                | Rhim, 2010 | Rhim Maternal use of proton pump inhibitors (PPI) during pregnancy is associated with an increased risk for cardiac birth defects: analysis of 208,951 pregnancies from the THIN database  Pharmacoepidemiol Drug Saf. 2010;138:S63  Rhim, A.D. Maternal use of proton pump inhibitors (PPI) during pregnancy is associated with an increased risk for cardiac birth defects: Analysis of 208,951 pregnancies from the GPRD/THIN database  Gastroenterology 2010; 138:S63-.  | 
            
            
                | Ruigomez - Omeprazole (Controls exposed to other treatment, sick), 1999 | Ruigomez Use of cimetidine, omeprazole, and ranitidine in pregnant women and pregnancy outcomes.  Am. J. Epidemiol. 1999; 150:476-81  | 
            
            
                | Ruigomez - Omeprazole (Controls unexposed NOS), 1999 | Ruigomez Use of cimetidine, omeprazole, and ranitidine in pregnant women and pregnancy outcomes.  Am. J. Epidemiol. 1999; 150:476-81  | 
            
            
                | Saleh, 2017 | Saleh Low Soluble Fms-Like Tyrosine Kinase-1, Endoglin, and Endothelin-1 Levels in Women With Confirmed or Suspected Preeclampsia Using Proton Pump Inhibitors.  Hypertension 2017; 70:594-600  | 
            
            
                | Van Gelder, 2022 | Van Gelder Associations Between Late-Onset Preeclampsia and the Use of Calcium-Based Antacids and Proton Pump Inhibitors During Pregnancy: A Prospective Cohort Study.  Clin Epidemiol 2022; 14:1229-1240  | 
            
            
                | Werler, 2014 | Werler Medication use in pregnancy in relation to the risk of isolated clubfoot in offspring.  Am. J. Epidemiol. 2014; 180:86-93  | 
            
            
                | Wolfe (Controls exposed to other treatment, sick), 2019 | Wolfe Prenatal use of medications for gastroesophageal reflux disease and early childhood fracture risk.  Birth 2019; 46:656-662  | 
            
            
                | Wolfe (Controls unexposed NOS), 2019 | Wolfe Prenatal use of medications for gastroesophageal reflux disease and early childhood fracture risk.  Birth 2019; 46:656-662  | 
            
            
                | Yitshak-Sade, 2016 | Yitshak-Sade Prenatal exposure to H2 blockers and to proton pump inhibitors and asthma development in offspring.  J Clin Pharmacol 2016; 56:116-23  |