Lamotrigine (Epilepsy)

Study Reference
Alsfouk, 2021

Alsfouk, B.A. Antiseizure medications use during pregnancy and congenital malformations: A retrospective study in Saudi Arabia Saudi Pharm. J. 2021; 29:939-.

AlSheikh, 2020

AlSheikh Prevalence of epilepsy in Saudi pregnant women and possible effects of anti-epileptic drugs on pregnancy outcomes. Neurosciences (Riyadh) 2020; 25:32-37

Artama (Controls unexposed, disease free), 2013

Artama Effects of maternal epilepsy and antiepileptic drug use during pregnancy on perinatal health in offspring: nationwide, retrospective cohort study in Finland. Drug Saf 2013; 36:359-69

Artama (Controls unexposed, sick), 2013

Artama Effects of maternal epilepsy and antiepileptic drug use during pregnancy on perinatal health in offspring: nationwide, retrospective cohort study in Finland. Drug Saf 2013; 36:359-69

Aydin, 2020

Aydin Retrospective evaluation of pregnancy outcomes with maternal epilepsy. Journal of Clinical Obstetrics and Gynecology 2020; 30:20-

Baker (Controls unexposed, disease free), 2015

Baker IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. Neurology 2015; 84:382-90

Bromley The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013; 84:637-43

Baker (Controls unexposed, sick), 2015

Baker IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. Neurology 2015; 84:382-90

Bromley The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013; 84:637-43

Bjørk (Controls unexposed, disease free), 2018

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Bjørk (Controls unexposed, NOS), 2022

Bjørk Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. JAMA Neurol 2022; :

Bjørk (Controls unexposed, sick), 2022

Bjørk Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. JAMA Neurol 2022; :

Bjørk (Controls unexposed, sick), 2018

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Borthen (Controls unexposed, disease free), 2011

Borthen Delivery outcome of women with epilepsy: a population-based cohort study. BJOG 2010; 117:1537-43

Borthen Obstetric outcome in women with epilepsy: a hospital-based, retrospective study. BJOG 2011; 118:956-65

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J Neurol 2014; 261:579-88

Borthen (Controls unexposed, disease free), 2010

Borthen Delivery outcome of women with epilepsy: a population-based cohort study. BJOG 2010; 117:1537-43

Borthen (Controls unexposed, sick), 2010

Borthen Delivery outcome of women with epilepsy: a population-based cohort study. BJOG 2010; 117:1537-43

Borthen (Controls unexposed, sick), 2011

Borthen Delivery outcome of women with epilepsy: a population-based cohort study. BJOG 2010; 117:1537-43

Borthen Obstetric outcome in women with epilepsy: a hospital-based, retrospective study. BJOG 2011; 118:956-65

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J Neurol 2014; 261:579-88

Bromley (Controls unexposed, disease free), 2010

Baker IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. Neurology 2015; 84:382-90

Bromley Early cognitive development in children born to women with epilepsy: a prospective report. Epilepsia 2010; 51:2058-65

Bromley The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013; 84:637-43

Bromley (Controls unexposed, disease free), 2013

Bromley Autism spectrum disorders following in utero exposure to antiepileptic drugs. Neurology 2008; 71:1923-4

Bromley The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013; 84:637-43

Bromley (Controls unexposed, sick), 2010

Baker IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. Neurology 2015; 84:382-90

Bromley Early cognitive development in children born to women with epilepsy: a prospective report. Epilepsia 2010; 51:2058-65

Bromley The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013; 84:637-43

Bromley (Controls unexposed, sick), 2013

Bromley Autism spectrum disorders following in utero exposure to antiepileptic drugs. Neurology 2008; 71:1923-4

Bromley The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013; 84:637-43

Bromley (Lamotrigine) (Epilepsy), 2023

Bromley Neurodevelopment of babies born to mothers with epilepsy: A prospective observational cohort study. Epilepsia 2023; 64:2454-2471

Campbell, 2014

Campbell E Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J Neurol Neurosurg Psychiatry 2014;85:1029-34

Morrow Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006; 77:193-8

Cassina, 2013

Cassina Pregnancy outcome in women exposed to antiepileptic drugs: teratogenic role of maternal epilepsy and its pharmacologic treatment. Reprod Toxicol 2013; 39:50-7

Charlton, 2011

Charlton Comparing the General Practice Research Database and the UK Epilepsy and Pregnancy Register as tools for postmarketing teratogen surveillance: anticonvulsants and the risk of major congenital malformations. Drug Saf 2011; 34:157-71

Morrow Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006; 77:193-8

Charlton (Controls unexposed, disease free), 2017

Bromley The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013; 84:637-43

Charlton Sensitivity of the UK Clinical Practice Research Datalink to Detect Neurodevelopmental Effects of Medicine Exposure in Utero: Comparative Analysis of an Antiepileptic Drug-Exposed Cohort. Drug Saf 2017; 40:387-397

Charlton (Controls unexposed, sick), 2017

Bromley The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013; 84:637-43

Charlton Sensitivity of the UK Clinical Practice Research Datalink to Detect Neurodevelopmental Effects of Medicine Exposure in Utero: Comparative Analysis of an Antiepileptic Drug-Exposed Cohort. Drug Saf 2017; 40:387-397

Cohen, 2019

Cohen Anticonvulsant Mood Stabilizer and Lithium Use and Risk of Adverse Pregnancy Outcomes. J Clin Psychiatry 2019; 80:

Cohen-Israel, 2018

Cohen-Israel Short- and long-term complications of in utero exposure to lamotrigine. Br J Clin Pharmacol 2018; 84:189-194

Cummings, 2011

Cummings Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine. Arch Dis Child 2011; 96:643-7

Dean, 2007

Dean Fetal anticonvulsant syndromes and polymorphisms in MTHFR, MTR, and MTRR. Am J Med Genet A 2007; 143A:2303-11

Diav-Citrin, 2017

Diav-Citrin Is it safe to use lamotrigine during pregnancy? A prospective comparative observational study. Birth Defects Res 2017; 109:1196-1203

Rihtman Developmental outcomes at preschool age after fetal exposure to valproic acid and lamotrigine: cognitive, motor, sensory and behavioral function. Reprod Toxicol 2013; 41:115-25

Dreier, 2021

Dreier, J. Prenatal exposure to antiseizure medication and intrauterine growth restriction in offspring of women with epilepsy. Epilepsia 2021; 62:6-.

Dreier, 2023

Dreier Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders. JAMA Neurol 2023; 80:568-577

Gopinath, 2015

Gopinath Children (10-12 years age) of women with epilepsy have lower intelligence, attention and memory: Observations from a prospective cohort case control study. Epilepsy Res 2015; 117:58-62

He, 2017

He Pregnancy outcome in women with epilepsy in Western China: A prospective hospital based study. Epilepsy Behav 2017; 74:10-14

Holmes, 2008

Holmes Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy. Neurology 2008; 70:2152-8

Hosny, 2021

Hosny Risk factors of fetal deaths and major birth defects in newborns of women with epilepsy: An Egyptian prospective study. Epilepsy Behav 2021; 123:108251

Husebye (Controls unexposed, disease free), 2020

Husebye Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study. Eur J Neurol 2020; 27:667-675

Husebye (Controls unexposed, sick), 2020

Husebye Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study. Eur J Neurol 2020; 27:667-675

Kasradze, 2017

Kasradze Cognitive functions in children exposed to antiepileptic drugs in utero - Study in Georgia. Epilepsy Behav 2017; 66:105-112

Kini, 2006

Kini Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes. Arch Dis Child Fetal Neonatal Ed 2006; 91:F90-5

Li, 2023

He Pregnancy outcome in women with epilepsy in Western China: A prospective hospital based study. Epilepsy Behav 2017; 74:10-14

Li Pregnancy characteristics and adverse outcomes in offspring of women with epilepsy: a prospective registry study from Mainland China. Front Neurol 2023; 14:1195003

Mawer (Controls unexposed, disease free), 2010

Kini Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero. Eur J Med Genet ; 50:411-20

Mawer Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study. Seizure 2010; 19:112-9

Mawer (Controls unexposed, sick), 2010

Kini Influence of the MTHFR genotype on the rate of malformations following exposure to antiepileptic drugs in utero. Eur J Med Genet ; 50:411-20

Mawer Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study. Seizure 2010; 19:112-9

Meador, 2023

Meador Two-Year-Old Cognitive Outcomes in Children of Pregnant Women With Epilepsy in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study. JAMA Neurol 2021; 78:927-936

Meador Cognitive outcomes at age 3 years in children with fetal exposure to antiseizure medications (MONEAD study) in the USA: a prospective, observational cohort study. Lancet Neurol 2023; 22:712-722

Meador (Controls unexposed, disease free), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

Meador (Controls unexposed, sick), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

Miškov (Controls unexposed, disease free), 2016

Miskov Croatian Pregnant Women with Epilepsy and Effects of Antiepileptic Drugs Exposure in their Offspring - seven years of prospective surveillance. American Epilepsy Society; Texas 2010

Miškov (Controls unexposed, sick), 2016

Miskov Croatian Pregnant Women with Epilepsy and Effects of Antiepileptic Drugs Exposure in their Offspring - seven years of prospective surveillance. American Epilepsy Society; Texas 2010

Pekoz (Lamotrigine) (Epilepsy), 2023

Pekoz Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Turkiye. Epilepsia 2023; 64:2310-2321

Petersen (Controls unexposed NOS), 2017

Petersen Antiepileptic drugs prescribed in pregnancy and prevalence of major congenital malformations: comparative prevalence studies. Clin Epidemiol 2017; 9:95-103

Petersen (Controls unexposed, sick), 2017

Petersen Antiepileptic drugs prescribed in pregnancy and prevalence of major congenital malformations: comparative prevalence studies. Clin Epidemiol 2017; 9:95-103

Razaz (Controls unexposed, disease free), 2017

Razaz Association Between Pregnancy and Perinatal Outcomes Among Women With Epilepsy. JAMA Neurol 2017; 74:983-991

Razaz (Controls unexposed, sick), 2017

Razaz Association Between Pregnancy and Perinatal Outcomes Among Women With Epilepsy. JAMA Neurol 2017; 74:983-991

Ren (Lamotrigine) (Epilepsy), 2023

Elkjaer Association Between Prenatal Valproate Exposure and Performance on Standardized Language and Mathematics Tests in School-aged Children. JAMA Neurol 2018; 75:663-671

Ren Prenatal Carbamazepine Exposure and Academic Performance in Adolescents: A Population-Based Cohort Study. Neurology 2023; 100:e728-e738

Rihtman, 2013

Rihtman Developmental outcomes at preschool age after fetal exposure to valproic acid and lamotrigine: cognitive, motor, sensory and behavioral function. Reprod Toxicol 2013; 41:115-25

Thomas (Controls unexposed, disease free), 2021

Thomas Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India. Epilepsia 2017; 58:274-281

Thomas (Controls unexposed, sick), 2021

Thomas Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India. Epilepsia 2017; 58:274-281

Thomas Malformation risk of new anti-epileptic drugs in women with epilepsy; observational data from the Kerala registry of epilepsy and pregnancy (KREP). Seizure 2021; 93:127-132

Trivedi, 2018

Trivedi Spontaneous fetal loss in women with epilepsy: prospective data from pregnancy registry in India. Epilepsy Res 2018; 146:50-53

Vajda, 2018

Vajda Anti-epileptic drug exposure and risk of foetal death in utero. Acta Neurol Scand 2018; 137:20-23

Vajda, 2019

Vajda Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. Seizure 2010; 19:558-61

Vajda Teratogenicity of the newer antiepileptic drugs--the Australian experience. J Clin Neurosci 2012; 19:57-9

Vajda The prescribing of antiepileptic drugs for pregnant Australian women. Aust N Z J Obstet Gynaecol 2012; 52:49-53

Vajda Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurol Scand 2013; 128:228-34

Vajda The teratogenic risk of antiepileptic drug polytherapy. Epilepsia 2010; 51:805-10

Vajda The Australian Register of Antiepileptic Drugs in Pregnancy: the first 1002 pregnancies. Aust N Z J Obstet Gynaecol 2007; 47:468-74

Vajda Changing Australian prescribing patterns for antiepileptic drugs in pregnancy and their possible consequences. J Clin Neurosci 2007; 14:611-7

Vajda Australian pregnancy registry of women taking antiepileptic drugs. Epilepsia 2004; 45:1466

Vajda Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11

Vajda The teratogenicity of the newer antiepileptic drugs - an update. Acta Neurol Scand 2014; 130:234-8

Vajda, 2013

Vajda Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurol Scand 2013; 128:228-34

Vajda Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11

Van Marter (Controls unexposed, disease free), 2021

Van Marter, L.J. Neonatal Outcomes in the MONEAD Study of Pregnant Women with Epilepsy Journal of Pediatrics: X 2021; 7:514-.

Van Marter (Controls unexposed, sick), 2021

Van Marter, L.J. Neonatal Outcomes in the MONEAD Study of Pregnant Women with Epilepsy Journal of Pediatrics: X 2021; 7:514-.

Vanya (Controls unexposed, sick), 2015

Vanya EFFECTS OF MATERNAL EPILEPSY AND ANTIEPILEPTIC THERAPY IN WOMEN DURING PREGNANCY. Ideggyogy Sz 2015; 68:105-12

Veiby (Controls unexposed, disease free), 2014

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J Neurol 2014; 261:579-88

Veiby (Controls unexposed, disease free) a, 2013

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Veiby Exposure to antiepileptic drugs in utero and child development: a prospective population-based study. Epilepsia 2013; 54:1462-72

Veiby Early child development and exposure to antiepileptic drugs prenatally and through breastfeeding: a prospective cohort study on children of women with epilepsy. JAMA Neurol 2013; 70:1367-74

Veiby (Controls unexposed, disease free) b, 2013

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Farmen Intrauterine growth retardation in foetuses of women with epilepsy. Seizure 2015; 28:76-80

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J Neurol 2014; 261:579-88

Veiby Exposure to antiepileptic drugs in utero and child development: a prospective population-based study. Epilepsia 2013; 54:1462-72

Veiby (Controls unexposed, sick), 2014

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J Neurol 2014; 261:579-88

Veiby (Controls unexposed, sick) a, 2013

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Veiby Exposure to antiepileptic drugs in utero and child development: a prospective population-based study. Epilepsia 2013; 54:1462-72

Veiby Early child development and exposure to antiepileptic drugs prenatally and through breastfeeding: a prospective cohort study on children of women with epilepsy. JAMA Neurol 2013; 70:1367-74

Veiby (Controls unexposed, sick) b, 2013

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Farmen Intrauterine growth retardation in foetuses of women with epilepsy. Seizure 2015; 28:76-80

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J Neurol 2014; 261:579-88

Veiby Exposure to antiepileptic drugs in utero and child development: a prospective population-based study. Epilepsia 2013; 54:1462-72

Videman, 2016

Videman Evidence for spared attention to faces in 7-month-old infants after prenatal exposure to antiepileptic drugs. Epilepsy Behav 2016; 64:62-68

Wiggs, 2020

Wiggs Antiseizure medication use during pregnancy and risk of ASD and ADHD in children. Neurology 2020; 95:e3232-e3240