Levetiracetam (All indications)

Study Reference
Alsfouk (Levetiracetam), 2022

Alsfouk, B.A. Patterns of antiseizure medication prescription in pregnancy and maternal complications in women with epilepsy: A retrospective study in Saudi Arabia Saudi Pharm. J. 2022; 30:205-.

Alsfouk (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2021

Alsfouk, B.A. Antiseizure medications use during pregnancy and congenital malformations: A retrospective study in Saudi Arabia Saudi Pharm. J. 2021; 29:939-.

Alsfouk (Levetiracetam) (Controls unexposed, sick), 2021

Alsfouk, B.A. Antiseizure medications use during pregnancy and congenital malformations: A retrospective study in Saudi Arabia Saudi Pharm. J. 2021; 29:939-.

AlSheikh (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2020

AlSheikh Prevalence of epilepsy in Saudi pregnant women and possible effects of anti-epileptic drugs on pregnancy outcomes. Neurosciences (Riyadh) 2020; 25:32-37

AlSheikh (Levetiracetam) (Controls unexposed, sick), 2020

AlSheikh Prevalence of epilepsy in Saudi pregnant women and possible effects of anti-epileptic drugs on pregnancy outcomes. Neurosciences (Riyadh) 2020; 25:32-37

Arkilo (Levetiracetam), 2015

Arkilo D Pregnancy and neurodevelopmental outcomes with in-utero antiepileptic agent exposure. A pilot study. Eur J Paediatr Neurol 2015;19:37-40

Artama (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2013

Artama M Effects of maternal epilepsy and antiepileptic drug use during pregnancy on perinatal health in offspring: nationwide, retrospective cohort study in Finland. Drug Saf 2013;36:359-69

Artama (Levetiracetam) (Controls unexposed, disease free), 2013

Artama M Effects of maternal epilepsy and antiepileptic drug use during pregnancy on perinatal health in offspring: nationwide, retrospective cohort study in Finland. Drug Saf 2013;36:359-69

Artama (Levetiracetam) (Controls unexposed, sick), 2013

Artama M Effects of maternal epilepsy and antiepileptic drug use during pregnancy on perinatal health in offspring: nationwide, retrospective cohort study in Finland. Drug Saf 2013;36:359-69

Aydin (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2020

Aydin, E. Retrospective evaluation of pregnancy outcomes with maternal epilepsy Journal of Clinical Obstetrics and Gynecology 2020; 30:20-.

Aydin (Levetiracetam) (Controls unexposed, sick), 2020

Aydin, E. Retrospective evaluation of pregnancy outcomes with maternal epilepsy Journal of Clinical Obstetrics and Gynecology 2020; 30:20-.

Babic (Levetiracetam), 2014

Babic Postnatal concerns in children born to women with juvenile myoclonic epilepsy. In: European Congress on Epileptology. vol. 55. Stockholm: Epilepsia; 2014: 128

Bank (Levetiracetam) (Mixed indications), 2017

Bank Placental passage of antiepileptic drugs at delivery and neonatal outcomes. Epilepsia 2017; 58:e82-e86

Bech (Levetiracetam) (Mixed indications), 2018

Bech In utero exposure to antiepileptic drugs is associated with learning disabilities among offspring. J Neurol Neurosurg Psychiatry 2018; 89:1324-1331

Bjørk (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2022

Bjørk Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. JAMA Neurol 2022; :

Bjørk (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2018

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Bjørk (Levetiracetam) (Controls unexposed NOS), 2022

Bjørk Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. JAMA Neurol 2022; :

Bjørk (Levetiracetam) (Controls unexposed, disease free), 2018

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Bjørk (Levetiracetam) (Controls unexposed, sick), 2018

Bjørk Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero. JAMA Neurol 2018; 75:160-168

Bjørk (Levetiracetam) (Controls unexposed, sick), 2022

Bjørk Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. JAMA Neurol 2022; :

Blotière (Levetiracetam) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019

Blotière Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs. Neurology 2019; 93:e167-e180

Blotière (Levetiracetam) (Controls unexposed NOS) (Mixed indications), 2019

Blotière Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs. Neurology 2019; 93:e167-e180

Bromley (Levetiracetam), 2016

Bromley RL Cognition in school-age children exposed to levetiracetam, topiramate, or sodium valproate. Neurology 2016;87:1943-1953

Bromley (Levetiracetam) (Epilepsy) (Controls exposed to LTG), 2023

Bromley Neurodevelopment of babies born to mothers with epilepsy: A prospective observational cohort study. Epilepsia 2023; 64:2454-2471

Bromley (Levetiracetam) (Epilepsy) (Controls unexposed, sick), 2023

Bromley Neurodevelopment of babies born to mothers with epilepsy: A prospective observational cohort study. Epilepsia 2023; 64:2454-2471

Cohen (Levetiracetam) (Epilepsy) (Controls exposed to LTG), 2023

Christensen Prenatal exposure to valproate and risk of congenital malformations-Could we have known earlier?-A population-based cohort study. Epilepsia 2021; 62:2981-2993

Cohen Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations. Ann Neurol 2023; 93:551-562

Cohen (Levetiracetam) (Epilepsy) (Controls unexposed, NOS), 2023

Christensen Prenatal exposure to valproate and risk of congenital malformations-Could we have known earlier?-A population-based cohort study. Epilepsia 2021; 62:2981-2993

Cohen Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations. Ann Neurol 2023; 93:551-562

Coste (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2020

Blotière Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study. BMJ Open 2020; 10:e034829

Coste Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France. Sci Rep 2020; 10:17362

Coste (Levetiracetam) (Controls unexposed, NOS), 2020

Coste Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France. Sci Rep 2020; 10:17362

Dreier (Levetiracetam), 2021

Dreier, J. Prenatal exposure to antiseizure medication and intrauterine growth restriction in offspring of women with epilepsy. Epilepsia 2021; 62:6-.

Dreier (Levetiracetam) (Epilepsy) (Controls exposed to LTG), 2023

Dreier Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders. JAMA Neurol 2023; 80:568-577

Dreier (Levetiracetam) (Epilepsy) (Controls unexposed, sick), 2023

Dreier Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders. JAMA Neurol 2023; 80:568-577

Hernández-Díaz (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2012

Hernández-Díaz Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012;78:1692-9

Lewis B. Holmes, M.D. (Director) Risk of malformations for specific AED in monotherapy and the control groups (Annual Update for 2022) https://www.aedpregnancyregistry.org/ (Consulted 05/2022)

Hernández-Díaz (Levetiracetam) (Controls unexposed, disease free), 2012

Hernández-Díaz Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012;78:1692-9

Lewis B. Holmes, M.D. (Director) Risk of malformations for specific AED in monotherapy and the control groups (Annual Update for 2022) https://www.aedpregnancyregistry.org/ (Consulted 05/2022)

Hosny (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2021

Hosny Risk factors of fetal deaths and major birth defects in newborns of women with epilepsy: An Egyptian prospective study. Epilepsy Behav 2021; 123:108251

Hosny (Levetiracetam) (Controls unexposed, sick), 2021

Hosny Risk factors of fetal deaths and major birth defects in newborns of women with epilepsy: An Egyptian prospective study. Epilepsy Behav 2021; 123:108251

Huber-Mollema (Levetiracetam), 2019

Huber-Mollema Behavioral problems in children of mothers with epilepsy prenatally exposed to valproate, carbamazepine, lamotrigine, or levetiracetam monotherapy. Epilepsia 2019; 60:1069-1082

Husebye (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2020

Husebye Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study. Eur J Neurol 2020; 27:667-675

Husebye (Levetiracetam) (Controls unexposed, disease free), 2020

Husebye Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study. Eur J Neurol 2020; 27:667-675

Husebye (Levetiracetam) (Controls unexposed, sick), 2020

Husebye Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study. Eur J Neurol 2020; 27:667-675

Källén (Levetiracetam) (Controls exposed to Lamotrigine, sick) (Indications NOS), 2013

Källén B The use of central nervous system active drugs during pregnancy. Pharmaceuticals (Basel) 2013;6:1221-86

Källén (Levetiracetam) (Controls unexposed, NOS) (Indications NOS), 2013

Källén B The use of central nervous system active drugs during pregnancy. Pharmaceuticals (Basel) 2013;6:1221-86

Kilic (Levetiracetam) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014

Kilic D Birth outcomes after prenatal exposure to antiepileptic drugs--a population-based study. Epilepsia 2014;55:1714-21

Kilic (Levetiracetam) (Controls unexposed NOS) (Mixed indications), 2014

Kilic D Birth outcomes after prenatal exposure to antiepileptic drugs--a population-based study. Epilepsia 2014;55:1714-21

Kilic (Levetiracetam) (Controls unexposed, sick) (Mixed indications), 2014

Kilic D Birth outcomes after prenatal exposure to antiepileptic drugs--a population-based study. Epilepsia 2014;55:1714-21

Koc (Levetiracetam), 2018

Koc Fetal safety of levetiracetam use during pregnancy. Acta Neurol Belg 2018; 118:503-508

Li (Levetiracetam) (Controls exposed to LTG), 2023

He Pregnancy outcome in women with epilepsy in Western China: A prospective hospital based study. Epilepsy Behav 2017; 74:10-14

Li Pregnancy characteristics and adverse outcomes in offspring of women with epilepsy: a prospective registry study from Mainland China. Front Neurol 2023; 14:1195003

Li (Levetiracetam) (Controls unexposed, sick), 2023

He Pregnancy outcome in women with epilepsy in Western China: A prospective hospital based study. Epilepsy Behav 2017; 74:10-14

Li Pregnancy characteristics and adverse outcomes in offspring of women with epilepsy: a prospective registry study from Mainland China. Front Neurol 2023; 14:1195003

Mari (Levetiracetam), 2022

Mari Levetiracetam, lamotrigine and carbamazepine: which monotherapy during pregnancy? Neurol Sci 2022; 43:1993-2001

Meador (Controls exposed to LTG), 2023

Meador Two-Year-Old Cognitive Outcomes in Children of Pregnant Women With Epilepsy in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study. JAMA Neurol 2021; 78:927-936

Meador Cognitive outcomes at age 3 years in children with fetal exposure to antiseizure medications (MONEAD study) in the USA: a prospective, observational cohort study. Lancet Neurol 2023; 22:712-722

Meador (Controls unexposed, disease free), 2023

Meador Two-Year-Old Cognitive Outcomes in Children of Pregnant Women With Epilepsy in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study. JAMA Neurol 2021; 78:927-936

Meador Cognitive outcomes at age 3 years in children with fetal exposure to antiseizure medications (MONEAD study) in the USA: a prospective, observational cohort study. Lancet Neurol 2023; 22:712-722

Meador (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

Meador (Levetiracetam) (Controls unexposed, disease free), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

Meador (Levetiracetam) (Controls unexposed, sick), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

Morrow (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2006

Morrow J Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193-8

Morrow (Levetiracetam) (Controls unexposed, sick), 2006

Morrow J Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193-8

Pekoz (Levetiracetam) (Epilepsy) (Controls exposed to LTG), 2023

Pekoz Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Turkiye. Epilepsia 2023; 64:2310-2321

Pekoz (Levetiracetam) (Epilepsy) (Controls unexposed, sick), 2023

Pekoz Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Turkiye. Epilepsia 2023; 64:2310-2321

Richards (Levetiracetam) (Controls exposed to Lamotrigine, sick) (Indications NOS), 2019

Richards Developmental outcomes at age four following maternal antiepileptic drug use. Epilepsy Behav 2019; 93:73-79

Richards (Levetiracetam) (Controls unexposed, NOS) (Indications NOS), 2019

Richards Developmental outcomes at age four following maternal antiepileptic drug use. Epilepsy Behav 2019; 93:73-79

Shallcross (Levetiracetam), 2011

Shallcross Child development following in utero exposure: levetiracetam vs sodium valproate. Neurology 2011; 76:383-9

The NAAED (Controls exposed to Lamotrigine, sick) (Indications NOS), 2022

Hernández-Díaz Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012;78:1692-9

Lewis B. Holmes, M.D. (Director) Risk of malformations for specific AED in monotherapy and the control groups (Annual Update for 2022) https://www.aedpregnancyregistry.org/ (Consulted 05/2022)

The NAAED (Controls unexposed, disease free) (Indications NOS), 2022

Hernández-Díaz Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012;78:1692-9

Lewis B. Holmes, M.D. (Director) Risk of malformations for specific AED in monotherapy and the control groups (Annual Update for 2022) https://www.aedpregnancyregistry.org/ (Consulted 05/2022)

Thomas (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2021

Keni Teratogenicity of antiepileptic dual therapy: Dose-dependent, drug-specific, or both? Neurology 2018; 90:e790-e796

Thomas Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India. Epilepsia 2017; 58:274-281

Thomas Malformation risk of new anti-epileptic drugs in women with epilepsy; observational data from the Kerala registry of epilepsy and pregnancy (KREP). Seizure 2021; 93:127-132

Thomas (Levetiracetam) (Controls unexposed, disease free), 2021

Thomas Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India. Epilepsia 2017; 58:274-281

Thomas (Levetiracetam) (Controls unexposed, sick), 2021

Thomas Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India. Epilepsia 2017; 58:274-281

Thomas Malformation risk of new anti-epileptic drugs in women with epilepsy; observational data from the Kerala registry of epilepsy and pregnancy (KREP). Seizure 2021; 93:127-132

Tomson (Levetiracetam), 2018

Martinez Ferri Comparative study of antiepileptic drug use during pregnancy over a period of 12 years in Spain. Efficacy of the newer antiepileptic drugs lamotrigine, levetiracetam, and oxcarbazepine. Neurologia 2018; 33:78-84

Tomson Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol 2018; 17:530-538

Tomson T Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011;10:609-17

Tomson (Levetiracetam), 2015

Tomson T Antiepileptic drugs and intrauterine death: A prospective observational study from EURAP. Neurology 2015;85:580-8

Trivedi (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2018

Trivedi Spontaneous fetal loss in women with epilepsy: prospective data from pregnancy registry in India. Epilepsy Res 2018; 146:50-53

Trivedi (Levetiracetam) (Controls unexposed, sick), 2018

Trivedi Spontaneous fetal loss in women with epilepsy: prospective data from pregnancy registry in India. Epilepsy Res 2018; 146:50-53

Vajda (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2019

Vajda Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. Seizure 2010; 19:558-61

Vajda Teratogenicity of the newer antiepileptic drugs--the Australian experience. J Clin Neurosci 2012; 19:57-9

Vajda The prescribing of antiepileptic drugs for pregnant Australian women. Aust N Z J Obstet Gynaecol 2012; 52:49-53

Vajda Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurol. Scand. 2013; 128:228-34

Vajda The teratogenic risk of antiepileptic drug polytherapy. Epilepsia 2010; 51:805-10

Vajda The Australian Register of Antiepileptic Drugs in Pregnancy: the first 1002 pregnancies. Aust N Z J Obstet Gynaecol 2007; 47:468-74

Vajda Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11

Vajda FJ The teratogenicity of the newer antiepileptic drugs - an update. Acta Neurol Scand 2014;130:234-8

Vajda (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2018

Vajda Anti-epileptic drug exposure and risk of foetal death in utero. Acta Neurol Scand 2018; 137:20-23

Vajda (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2013

Vajda Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11

Vajda Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurol. Scand. 2013; 128:228-34

Vajda (Levetiracetam) (Controls unexposed, sick), 2019

Vajda Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. Seizure 2010; 19:558-61

Vajda Teratogenicity of the newer antiepileptic drugs--the Australian experience. J Clin Neurosci 2012; 19:57-9

Vajda The prescribing of antiepileptic drugs for pregnant Australian women. Aust N Z J Obstet Gynaecol 2012; 52:49-53

Vajda Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurol. Scand. 2013; 128:228-34

Vajda The teratogenic risk of antiepileptic drug polytherapy. Epilepsia 2010; 51:805-10

Vajda The Australian Register of Antiepileptic Drugs in Pregnancy: the first 1002 pregnancies. Aust N Z J Obstet Gynaecol 2007; 47:468-74

Vajda Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11

Vajda FJ The teratogenicity of the newer antiepileptic drugs - an update. Acta Neurol Scand 2014;130:234-8

Vajda (Levetiracetam) (Controls unexposed, sick), 2018

Vajda Anti-epileptic drug exposure and risk of foetal death in utero. Acta Neurol Scand 2018; 137:20-23

Vajda (Levetiracetam) (Controls unexposed, sick), 2013

Vajda Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurol Scand 2013; 128:228-34

Vajda Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11

Van Marter (Levetiracetam) (Controls unexposed, disease free), 2021

Van Marter, L.J. Neonatal Outcomes in the MONEAD Study of Pregnant Women with Epilepsy Journal of Pediatrics: X 2021; 7:514-.

Van Marter (Levetiracetam) (Controls unexposed, sick), 2021

Van Marter, L.J. Neonatal Outcomes in the MONEAD Study of Pregnant Women with Epilepsy Journal of Pediatrics: X 2021; 7:514-.

Veiby (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2014

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J. Neurol. 2014; 261:579-88

Veiby (Levetiracetam) (Controls unexposed, disease free), 2014

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J. Neurol. 2014; 261:579-88

Veiby (Levetiracetam) (Controls unexposed, sick), 2014

Veiby Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J. Neurol. 2014; 261:579-88

Videman (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2016

Videman Evidence for spared attention to faces in 7-month-old infants after prenatal exposure to antiepileptic drugs. Epilepsy Behav 2016; 64:62-68

Videman (Levetiracetam) (Controls unexposed, disease free), 2016

Videman Evidence for spared attention to faces in 7-month-old infants after prenatal exposure to antiepileptic drugs. Epilepsy Behav 2016; 64:62-68