Zonisamide (All indications)

Study Reference
Battino (Zonisamide) (Epilepsy), 2024

Battino Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy. JAMA Neurol 2024; 81:481-489

Tomson Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol 2018; 17:530-538

Tomson Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011; 10:609-17

Hernández-Díaz (Zonisamide), 2017

Hernández-Díaz Fetal growth and premature delivery in pregnant women on antiepileptic drugs. Ann Neurol 2017; 82:457-465

Hernández-Díaz (Zonisamide) (Controls exposed to Lamotrigine, sick), 2014

Hernández-Díaz Fetal growth and premature delivery in pregnant women on antiepileptic drugs. Ann Neurol 2017; 82:457-465

Hernández-Díaz Association between topiramate and zonisamide use during pregnancy and low birth weight. Obstet Gynecol 2014; 123:21-28

Hernández-Díaz (Zonisamide) (Controls unexposed, disease free), 2014

Hernández-Díaz Fetal growth and premature delivery in pregnant women on antiepileptic drugs. Ann Neurol 2017; 82:457-465

Hernández-Díaz Association between topiramate and zonisamide use during pregnancy and low birth weight. Obstet Gynecol 2014; 123:21-28

Källén (Zonisamide) (Controls exposed to Lamotrigine, sick) (Indications NOS), 2013

Källén The use of central nervous system active drugs during pregnancy. Pharmaceuticals (Basel) 2013; 6:1221-86

Källén (Zonisamide) (Controls unexposed, NOS) (Indications NOS), 2013

Källén The use of central nervous system active drugs during pregnancy. Pharmaceuticals (Basel) 2013; 6:1221-86

Meador (Zonisamide) (Controls exposed to Lamotrigine, sick), 2021

Meador Two-Year-Old Cognitive Outcomes in Children of Pregnant Women With Epilepsy in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study. JAMA Neurol 2021; 78:927-936

Meador (Zonisamide) (Controls exposed to Lamotrigine, sick), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

Meador (Zonisamide) (Controls unexposed, disease free), 2021

Meador Two-Year-Old Cognitive Outcomes in Children of Pregnant Women With Epilepsy in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study. JAMA Neurol 2021; 78:927-936

Meador (Zonisamide) (Controls unexposed, disease free), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

Meador (Zonisamide) (Controls unexposed, sick), 2020

Meador Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology 2020; 94:e1502-e1511

The Australian Pregnancy Register of Antiepileptic Drugs (Mixed indications) (Controls exposed to LTG), 2024

Perucca Epilepsy-pregnancy registries: An update. Epilepsia 2024; :

Vajda Teratogenicity of zonisamide and other little-used antiseizure medications. Seizure 2024; 117:198-201

The Australian Pregnancy Register of Antiepileptic Drugs (Mixed indications) (Controls unexposed, sick), 2024

Perucca Epilepsy-pregnancy registries: An update. Epilepsia 2024; :

Vajda Teratogenicity of zonisamide and other little-used antiseizure medications. Seizure 2024; 117:198-201

The Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls exposed to Lamotrigine), 2024

Perucca Epilepsy-pregnancy registries: An update. Epilepsia 2024; :

Thomas Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India. Epilepsia 2017; 58:274-281

Thomas Malformation risk of new anti-epileptic drugs in women with epilepsy; observational data from the Kerala registry of epilepsy and pregnancy (KREP). Seizure 2021; 93:127-132

The Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls unexposed, sick), 2024

Perucca Epilepsy-pregnancy registries: An update. Epilepsia 2024; :

Thomas Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India. Epilepsia 2017; 58:274-281

Thomas Malformation risk of new anti-epileptic drugs in women with epilepsy; observational data from the Kerala registry of epilepsy and pregnancy (KREP). Seizure 2021; 93:127-132

The NAAED (Zonisamide) (Controls exposed to LTG) (Indications NOS), 2024

Hernández-Díaz Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012;78:1692-9

Lewis B. Holmes, M.D. (Director) Risk of malformations for specific AED in monotherapy and the control groups (Latest Study Data - October 2023) https://www.aedpregnancyregistry.org/ (Consulted 05/2022)

Lewis Holmes Risk of malformations for specific AED in monotherapy and the control groups. Latest Study Data - October 2023. https://www.aedpregnancyregistry.org/ (Consulted September 2024)

Perucca Epilepsy-pregnancy registries: An update. Epilepsia 2024; :

The NAAED (Zonisamide) (Controls unexposed, disease free) (Indications NOS), 2024

Hernández-Díaz Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012;78:1692-9

Lewis B. Holmes, M.D. (Director) Risk of malformations for specific AED in monotherapy and the control groups (Annual Update for 2022) https://www.aedpregnancyregistry.org/ (Consulted 05/2022)

Lewis Holmes Risk of malformations for specific AED in monotherapy and the control groups. Latest Study Data - October 2023. https://www.aedpregnancyregistry.org/ (Consulted September 2024)

Perucca Epilepsy-pregnancy registries: An update. Epilepsia 2024; :

The UKIEPR (Epilepsy) (Controls exposed to Lamotrigine), 2024

Campbell Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J Neurol Neurosurg Psychiatry 2014; 85:1029-34

Morrow Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006; 77:193-8

Perucca Epilepsy-pregnancy registries: An update. Epilepsia 2024; :

The UKIEPR (Epilepsy) (Controls unexposed, sick), 2024

Campbell Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J Neurol Neurosurg Psychiatry 2014; 85:1029-34

Morrow Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006; 77:193-8

Perucca Epilepsy-pregnancy registries: An update. Epilepsia 2024; :