Triptans

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S850
R6548		 Bérard, 2012 Spontaneous abortions (anytime between the first day and the 20th week of gestation) during pregnancy (anytime or not specified) nested case control unexposed, disease free Adjustment: Yes 2.65 [1.57;4.48] 21/82   4,748/52,377 4,769 82
ref
Total 1 studies 2.65 [1.57;4.48] 4,769 82
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2012Bérard, 2012 2.65[1.57; 4.48]4,769820%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.65[1.57; 4.48]4,76982 -NABérard, 2012 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.65[1.57; 4.48]4,76982 -NABérard, 2012 1 Tags Adjustment   - Yes  - Yes 2.65[1.57; 4.48]4,76982 -NABérard, 2012 1 All studiesAll studies 2.65[1.57; 4.48]4,76982 -NABérard, 2012 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.91[0.99; 3.69]4,99361074%NASpielmann (Control unexposed, disease free), 2017 Bérard, 2012 Shuhaiber - Sumatriptan (Control unexposed, disease free), 1998 3 unexposed, sick controlsunexposed, sick controls 0.87[0.33; 2.28]1976 -NAO'Quinn - Sumatriptan, 1999 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.48[0.98; 2.23]1045280%NASpielmann (Control mainly exposed other treatments, sick), 2017 Shuhaiber - Sumatriptan (Control exposed to other treatments), 1998 20.510.01.0