Clorazepate

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Bonnot 2003	France 1976 - 1997 case control	European Institut of Genomutations (IEG), Lyon, France.	Infants with the studied congenital malformation.	Infants with a malformations other than this one studied.	The medical records are checked to obtain data on treatment intake and other exposures or risks.	1st trimester	-9 / -9	Total number of infants with a congenital malformation is 13703, but the number of cases changes according to the studied malformations. Raw data not sufficient to calculate OR (data for 'control' groups not available).
Bonnot 2003	France 1976 - 1997 case control	European Institut of Genomutations (IEG), Lyon, France.	After having defined a population, often on geographical criteria, these networks set up birth observatories in order to exhaustively identify neonatal malformations in their reference population.			1st trimester	-9 / -9

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;