Clozapine

Study	Exclusion reasons	Rmk	Reference
Shao (Control exposed to other SGA), 2015	inadequate or absent control group	EXCLUDED: Controls also exposed to atypical antipsychotics => No adequate control group. Disagreement with authors who defined this study as a prospective, case-controlled study rather than a cohort	Shao P PLoS One 2015;10:e0123373 10.1371/journal.pone.0123373
Dev, 1995	case report or case series	EXCLUDED: all pregnancies exposed to clozapine => No control group.	Dev Rev. Contcmp. Pharmacother. 1995; 6:197-208
Ellfolk, 2019	not relevant exposure	EXCLUDED: Gestational diabetes not reported because not sure that exposure occurred before outcome.	Ellfolk Eur J Clin Pharmacol 2020; 76:107-115 10.1007/s00228-019-02769-z
Galbally, 2020	not relevant exposure	EXCLUDED: Gestational diabetes not reported because not sure that exposure occurred before outcome.	Galbally Aust N Z J Obstet Gynaecol 2020; 60:63-69 10.1111/ajo.12986
Makikyro, 1998	not in pregnancy	EXCLUDED: no exposure during pregnancy. Characteristics of pregnancy, delivery, childhood (etc.) of men and women treated for schizophrenia assessed as potential factors for the psychotropic treatment.	Makikyro T J Psychiatr Res. 1998 Mar-Apr;32(2):105-10.