metaPreg - Clozapine during pregnancy

Clozapine updated on 06-10-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.79 [0.72, 4.47]	0%	4 studies	30,682	57	not evaluable	ROB	-
Major congenital malformations	1.79 [0.72, 4.47]	0%	4 studies	30,682	57	not evaluable	ROB	-
Ano-rectal atresia and stenosis	69.24 [9.75, 491.62]	-	1 study			not evaluable	ROB	137.98 [18.99; .]
Congenital heart defects	0.53 [0.07, 3.88]	-	1 study			not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Caesarean	-	-	0 study					-
Gestational diabetes	29.33 [4.12, 209.02]	-	1 study	10	11	not evaluable	ROB	58.16 [7.70; .]
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neonatal medical care	-	-	0 study					-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Intrauterine deaths (as a whole or unspecified)	15.67 [0.74, 331.22]	-	1 study	3	14	not evaluable	ROB	-
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