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Clozapine
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
McKenna, 2005 Reis (Unexposed control, NOS), 2008 Peng, 2013 Huybrechts (Controls unexposed, sick), 2023
4
1.79
[
0.72
; 4.47]
42,320
57
not evaluable
Major congenital malformations
McKenna, 2005 Reis (Unexposed control, NOS), 2008 Peng, 2013 Huybrechts (Controls unexposed, sick), 2023
4
1.79
[
0.72
; 4.47]
42,320
57
not evaluable
Ano-rectal atresia and stenosis
Huybrechts (Controls unexposed, NOS), 2023
1
69.24
[
9.75
; 491.62]
-
-
not evaluable
Congenital heart defects
Huybrechts (Controls unexposed, sick), 2023
1
0.53
[
0.07
; 3.88]
-
-
not evaluable
Maternal consequences
Caesarean
0
-
-
-
-
-
Gestational diabetes
Kulkarni, 2024
1
29.33
[
4.12
; 209.02]
10
11
not evaluable
Neonatal disorders
Neonatal medical care
0
-
-
-
-
-
Intrauterine deaths
Intrauterine deaths (as a whole or unspecified)
Kulkarni, 2024
1
15.67
[
0.74
; 331.22]
3
14
not evaluable
0.0
100.0
1.0
