Oxcarbazepine (All indications)


Study Exclusion reasons Rmk Reference
Vajda (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2018 Overlapping between Vajda 2024a (1999 - 2023) and Vajda 2018 (1999 - 2016) based on the same register and for the almost same outcome (with or without elective termination) => Use of Vajda 2024a because accounting for more relevant confounders.

Vajda Acta Neurol Scand 2018; 137:20-23 10.1111/ane.12816

Vajda (Oxcarbazepine) (Controls unexposed, sick), 2018 Overlapping between Vajda 2024a (1999 - 2023) and Vajda 2018 (1999 - 2016) based on the same register and for the almost same outcome (with or without elective termination) => Use of Vajda 2024a because accounting for more relevant confounders.

Vajda Acta Neurol Scand 2018; 137:20-23 10.1111/ane.12816

Christensen (Oxcarbazepine) (Controls exposed to Lamotrigine, sick) (Indications NOS), 2019 Indications not specified. Overlapping: For ADHD: Christensen 2019 totally included in a larger study published by Dreier 2023 (longer study period and 5 countries) => use of Dreier 2023 data.

Christensen JAMA Netw Open 2019; 2:e186606 10.1001/jamanetworkopen.2018.6606

Christensen (Oxcarbazepine) (Controls unexposed NOS) (Indications NOS), 2019 Indications not specified. Overlapping: For ADHD: Christensen 2019 totally included in a larger study published by Dreier 2023 (longer study period and 5 countries) => use of Dreier 2023 data.

Christensen JAMA Netw Open 2019; 2:e186606 10.1001/jamanetworkopen.2018.6606

Coste (Oxcarbazepine) (Controls unexposed, sick), 2020 EXCLUDED: this control group doesn't exist in the article (only in the report). Children with a diagnosis of brain malformation (ICD-10 codes Q00 to Q04 and Q05.0 to Q05.4) during their stay in the maternity unit are excluded.

Coste Sci Rep 2020; 10:17362 10.1038/s41598-020-74409-x

Daugaard (Oxcarbazepine) (Controls exposed to Lamotrigine, sick) (Indications NOS), 2020 Indications not specified. Overlapping between Bjork 2022 and Daugaard 2020 for Intellectual disabilities (2 outcomes), with more pregnancies in Bjork 2022 because longer study period and 5 countries => use of Bjork 2022 data.

Daugaard JAMA Netw Open 2020; 3:e2025570 10.1001/jamanetworkopen.2020.25570

Daugaard (Oxcarbazepine) (Controls unexposed NOS) (Indications NOS), 2020 Indications not specified. Overlapping between Bjork 2022 and Daugaard 2020 for Intellectual disabilities (2 outcomes), with more pregnancies in Bjork 2022 because longer study period and 5 countries => use of Bjork 2022 data.

Daugaard JAMA Netw Open 2020; 3:e2025570 10.1001/jamanetworkopen.2020.25570

He (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2017 repeat population groups, duplicate reports (most recent study included) Patients who developed epilepsy during pregnancy or after delivery were not included. Overlapping: He 2017 totally included in Li 2023, with a longer study period and more pregnancies => Use of Li 2023.

He Epilepsy Behav 2017; 74:10-14 10.1016/j.yebeh.2017.05.034

He (Oxcarbazepine) (Controls unexposed, sick), 2017 repeat population groups, duplicate reports (most recent study included) Patients who developed epilepsy during pregnancy or after delivery were not included. Overlapping: He 2017 totally included in Li 2023, with a longer study period and more pregnancies => Use of Li 2023.

He Epilepsy Behav 2017; 74:10-14 10.1016/j.yebeh.2017.05.034

Vajda b (Oxcarbazepine) (Epilepsy), 2024 same data already obtained by other studies EXCLUDED: Partial overlapping with Battino 2024, no details on the period of exposure during pregnancy, and congenital malformations reported in Vajda 2019 (with T1 exposure).