Metoclopramide


Study Exclusion reasons Rmk Reference
Yost, 2003 inadequate or absent control group EXCLUDED: Promethazine and metoclopramide were administrated in the 2 groups. No adequate control group.

Yost NP Obstet Gynecol 2003;102:1250-4

zNumazaki, 2000 other reason RETRACTATION. This article has been retracted at the request of the Editor-in-Chief, Dr. Robert R. Gaiser. The University of Toho, where Dr. Fujii was employed, determined that the integrity of the published data could not be verified or substantiated

zNumazaki M Anaesth Intensive Care 2000;28:262-5

zFujii, 1998 other reason EXCLUDED: THIS ARTICLE HAS BEEN RETRACTED.

zFujii Y Acta Anaesthesiol Scand 1998;42:921-5

zLacasse, 2009 other reason EXCLUDED: Results of neonate outcomes NOT exploitable (male to female sex ratio was significantly lower for the new HG protocol than in the control group (sex ratio: 0.41 vs. 1.03, respectively). No congenital malformations in the new HG protocol).

zLacasse A Eur J Obstet Gynecol Reprod Biol 2009;143:43-9 10.1016/j.ejogrb.2008.11.007
zNumazaki, 2003 other reason RETRACTATION. This article has been retracted at the request of the Editor-in-Chief, Dr. Robert R. Gaiser. The University of Toho, where Dr. Fujii was employed, determined that the integrity of the published data could not be verified or substantiated.

zNumazaki M J Clin Anesth 2003;15:423-7

Hastoy, 2015 not relevant study design EXCLUDED: the study did not assessed the impact of the treatment but to the impact of hyperemesis gravidarum (HG) on pregnancy (treatment are described but not analysed).

Hastoy A J Gynecol Obstet Biol Reprod (Paris) 2015;44:154-63 10.1016/j.jgyn.2013.12.003
Vella, 1985 not relevant outcome EXCLUDED: Apgar scores reported as continuous variables. All babies were born alive, with no significant difference in Apgar scores between the groups.

Vella L Br Med J (Clin Res Ed) 1985;290:1173-5

Abas, 2014 not relevant outcome EXCLUDED: safety outcomes only concerned adverse event in the mother, not related to pregnancy.

Abas MN Obstet Gynecol 2014;123:1272-9 10.1097/AOG.0000000000000242
zAgah, 2015 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zAgah J Eur J Clin Pharmacol 2015;71:657-662 10.1007/s00228-015-1845-8
zHabib, 2013 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zHabib AS Obstet Gynecol 2013;121:615-23 10.1097/AOG.0b013e3182839fee
zKlauser, 2011 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zKlauser CK Am J Perinatol 2011;28:715-21 10.1055/s-0031-1280594
zLi, 2012 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zLi JZ Zhonghua Yi Xue Za Zhi 2012;92:1892-5

zHabek, 2004 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zHabek D Forsch Komplementarmed Klass Naturheilkd 2004;11:20-3 10.1159/000077192
zGriffiths, 2012 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zGriffiths JD Cochrane Database Syst Rev 2012;:CD007579 10.1002/14651858.CD007579.pub2
zDanzer, 1997 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zDanzer BI Reg Anesth 1997;22:424-7

zParanjothy, 2010 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zParanjothy S Cochrane Database Syst Rev 2010;:CD004943 10.1002/14651858.CD004943.pub3
zParanjothy, 2014 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zParanjothy S Cochrane Database Syst Rev 2014;:CD004943 10.1002/14651858.CD004943.pub4
zMishriky, 2012 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zMishriky BM Br J Anaesth 2012;109:826 10.1093/bja/aes364
zMcParlin, 2016 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.
zMayhall, 2015 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zMayhall EA Am J Emerg Med 2015;33:882-6 10.1016/j.ajem.2015.03.032
zBondok, 2006 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zBondok RS Crit Care Med 2006;34:2781-3 10.1097/01.CCM.0000242156.15757.70
zRocke, 1994 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zRocke DA Anesth Analg 1994;78:1093-8

zTan, 2009 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zTan PC Gynecol Obstet Invest 2009;67:151-7 10.1159/000181182
zMohammadbeigi, 2011 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zMohammadbeigi R Pak J Biol Sci 2011;14:817-20

zTan, 2010 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zTan PC Obstet Gynecol 2010;115:975-81 10.1097/AOG.0b013e3181d99290
zPan, 2001 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zPan PH J Clin Anesth 2001;13:430-5

zDriver, 1996 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zDriver RP Jr Anesth Analg 1996;82:1033-5

zStein, 1997 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zStein DJ Anesth Analg 1997;84:342-5

zHamilton, 2018 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zHamilton KT Headache 2018;: 10.1111/head.13434
zO'Sullivan, 1985 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zO'Sullivan G Anaesthesia 1985;40:246-53

zMurphy, 1984 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zMurphy DF Br J Anaesth 1984;56:1113-6

zKimura, 2011 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zKimura M J Anesth 2011;25:692-7 10.1007/s00540-011-1203-7
zKashifard, 2013 not relevant outcome EXCLUDED: no exploitable result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

zKashifard M Clin Exp Obstet Gynecol 2013;40:127-30

Huseyinoglu, 2016 not relevant outcome EXCLUDED: no result related to adverse maternal outcomes in relation with pregnancy or to adverse fetal/neonatal outcomes.

Huseyinoglu Journal of Obstetrics and Gynecology of India 2016; 66:252-. 10.1007/s13224-015-0679-8
Berkovitch, 2000 repeat population groups, duplicate reports (most recent study included) EXCLUDED: study's results included in Berkovitch et al. 2002.

Berkovitch M N Engl J Med 2000;343:445-6 10.1056/NEJM200008103430616
zBifarini, 1992 article unavailable EXCLUDED: study on efficacy and not on safety (data not checked, article unavailable).

zBifarini G Minerva Anestesiol 1992;58:95-9

zBraun, 1994 article unavailable EXCLUDED: study on efficacy and not on safety (data not checked, article unavailable).

zBraun GG Anaesthesiol Reanim 1994;19:37-42

zMcGarry, 1973 no specific data EXCLUDED: no results.

zMcGarry J Postgrad Med J 1973;49 Suppl 4:suppl 4:51-2

Benevent, 2019 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Atropinic drugs analyzed as a whole without distinction between treatments.

Benevent Drug Saf 2019; 42:45-54 10.1007/s40264-018-0712-9
Ferreira, 2003 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: The group was intramuscular chlorpromazine, intravenous dimenhydrinate, intravenous metoclopramide, or a combination of doxylamine–pyridoxine, without distinction between treatments.

Ferreira, E. Journal of Pharmacy Technology 2003; 19:349-. 10.1177/875512250301900602
Banhidy, 2007 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: analysis according to illness status, without distinction between treatments.

Banhidy Eur. J. Obstet. Gynecol. Reprod. Biol. 2007; 134:157-63 10.1016/j.ejogrb.2006.08.025
Lenoir, 2020 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: analysis according to exposure to medications as a whole, without distinction between treatments.

Lenoir Eur. J. Obstet. Gynecol. Reprod. Biol. 2020; 247:42-48 10.1016/j.ejogrb.2020.01.042
zTan, 2018 pattern of exposure EXCLUDED: study on pattern of exposure, without fetal/maternal/neonate safety data.

zTan A Aust N Z J Obstet Gynaecol 2018;58:278-290 10.1111/ajo.12714
Das, 2016 pattern of exposure EXCLUDED: study on pattern of exposure, without fetal/maternal/neonate safety data.

Das Trop Doct 2016; 46:86-90 10.1177/0049475515609841
Fonseca, 2002 pattern of exposure EXCLUDED: data on pattern of exposure, without data on maternal/fetal/neonate safety outcomes.

Fonseca Rev Saude Publica 2002; 36:205-12 10.1590/s0034-89102002000200013
Olesen, 1999 pattern of exposure EXCLUDED: data on pattern of exposure, without data on maternal/fetal/neonate safety outcomes.

Olesen Acta Obstet Gynecol Scand 1999; 78:686-92 10.1034/j.1600-0412.1999.780805.x
Engeland, 2008 pattern of exposure EXCLUDED: study on pattern of exposure, without fetal/maternal/neonate safety data.

Engeland Br J Clin Pharmacol 2008; 65:653-60 10.1111/j.1365-2125.2008.03102.x

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