Metoclopramide

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.01 [0.95, 1.07]19%8 studies27,61586,141not evaluable ROB-
Major congenital malformations1.01 [0.94, 1.10]42%6 studies26,90785,897not evaluable ROB-
Hypospadias0.88 [0.68, 1.14]0%4 studies2,55313,276not evaluable ROB-
Cleft lip with or without cleft palate1.00 [0.77, 1.30]0%3 studies1,23381,317not evaluable ROB-
Cleft palate1.01 [0.63, 1.64]44%3 studies70181,318not evaluable ROB-
Atrial septal defect0.97 [0.78, 1.22]47%2 studies76681,295not evaluable ROB-
Congenital heart defects1.10 [0.77, 1.58]73%2 studies4,79653,748not evaluable ROB-
Ventricular septal defect0.86 [0.74, 1.00]12%2 studies1,03581,295not evaluable ROB-
Genital anomalies2.26 [1.14, 4.48]-1 study940939not evaluable ROB3.95 [1.54; .]
Patent ductus arterious1.64 [1.21, 2.23]-1 study13652,809not evaluable ROB2.66 [1.70; .]
27 non statistically significant endpoints reported in only one study

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.03 [0.89, 1.20]58%6 studies48,41641,944not evaluable ROB-
Low birth weight (< 2500g)0.95 [0.85, 1.07]72%5 studies34,83941,811not evaluable ROB-
Small for gestational age (weight)0.88 [0.59, 1.29]61%2 studies32,41038,030not evaluable ROB-
1 non statistically significant endpoints reported in only one study

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
2 non statistically significant endpoints reported in only one study

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low Apgar score (< 7) (at 1 min)1.05 [0.55, 2.01]0%5 studies37282not evaluable ROB-
Low Apgar score (< 7) (at 5 min)1.09 [0.15, 7.97]0%4 studies86not evaluable ROB-
Persistent pulmonary hypertension--0 study-
5 non statistically significant endpoints reported in only one study

Long term consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
1 non statistically significant endpoints reported in only one study

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine death (< 22 weeks)0.35 [0.33, 0.38]0%3 studies10,18338,150not evaluable ROB5.15 [.; 4.75]
Late intrauterine deaths (> 22 weeks)0.90 [0.76, 1.08]0%3 studies2,55344,073not evaluable ROB-
1 non statistically significant endpoints reported in only one study

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
1 non statistically significant endpoints reported in only one study

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