Metoclopramide

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.01 [0.95, 1.07]19%8 studies27,61586,141not evaluable ROB-
Major congenital malformations1.01 [0.94, 1.10]42%6 studies26,90785,897not evaluable ROB-
Hypospadias0.88 [0.68, 1.14]0%4 studies2,55313,276not evaluable ROB-
Cleft lip with or without cleft palate1.00 [0.77, 1.30]0%3 studies1,23381,317not evaluable ROB-
Cleft palate1.01 [0.63, 1.64]44%3 studies70181,318not evaluable ROB-
Atrial septal defect0.97 [0.78, 1.22]47%2 studies76681,295not evaluable ROB-
Congenital heart defects1.10 [0.77, 1.58]73%2 studies4,79653,748not evaluable ROB-
Ventricular septal defect0.86 [0.74, 1.00]12%2 studies1,03581,295not evaluable ROB-
Ano-rectal atresia and stenosis0.77 [0.36, 1.65]-1 study5228,486not evaluable ROB-
Atrioventricular septal defect0.60 [0.25, 1.44]-1 study852,809not evaluable ROB-
Club foot / Talipes equinovarus0.78 [0.55, 1.10]-1 study24728,486not evaluable ROB-
Coarctation of aorta1.28 [0.70, 2.35]-1 study6128,486not evaluable ROB-
Congenital cataract0.72 [0.35, 1.49]-1 study5928,486not evaluable ROB-
Congenital hydronephrosis1.18 [0.89, 1.57]-1 study28128,486not evaluable ROB-
Congenital skin disorders1.32 [0.68, 2.55]-1 study5128,486not evaluable ROB-
Craniosynostosis0.80 [0.48, 1.34]-1 study11028,486not evaluable ROB-
Digestive system anomalies1.36 [0.71, 2.60]-1 study1,221939not evaluable ROB-
Eye, ear, face and neck malformations0.98 [0.31, 3.13]-1 study581939not evaluable ROB-
Genital anomalies2.26 [1.14, 4.48]-1 study940939not evaluable ROB3.95 [1.54; .]
Hydrocephaly0.81 [0.42, 1.57]-1 study6628,486not evaluable ROB-
Limb defects1.09 [0.78, 1.52]-1 study6,432939not evaluable ROB-
Limb reduction defects (LRD)0.99 [0.53, 1.84]-1 study6928,486not evaluable ROB-
Minor congenital malformations1.10 [0.92, 1.31]-1 study2,8633,458not evaluable ROB-
Nervous system anomalies1.26 [0.56, 2.85]-1 study672939not evaluable ROB-
Neural Tube Defects0.81 [0.43, 1.51]-1 study7628,486not evaluable ROB-
Oro-facial clefts0.76 [0.55, 1.05]-1 study17452,809not evaluable ROB-
Patent ductus arterious1.64 [1.21, 2.23]-1 study13652,809not evaluable ROB2.66 [1.70; .]
Polydactyly0.99 [0.59, 1.67]-1 study9628,486not evaluable ROB-
Pulmonary valve stenosis1.17 [0.73, 1.87]-1 study10828,486not evaluable ROB-
Respiratory system anomalies1.29 [0.57, 2.91]-1 study762939not evaluable ROB-
Single ventricle0.88 [0.27, 2.90]-1 study52,809not evaluable ROB-
Spina bifida2.05 [0.23, 18.10]-1 study46939not evaluable ROB-
Syndactyly0.88 [0.51, 1.52]-1 study9328,486not evaluable ROB-
Tetralogy of Fallot1.12 [0.51, 2.44]-1 study4028,486not evaluable ROB-
Total anomalous pulm venous return1.30 [0.59, 2.89]-1 study452,809not evaluable ROB-
Transposition of the great vessels0.65 [0.28, 1.49]-1 study5128,486not evaluable ROB-
Urinary malformations0.95 [0.47, 1.92]-1 study1,727939not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.03 [0.89, 1.20]58%6 studies48,41641,944not evaluable ROB-
Low birth weight (< 2500g)0.95 [0.85, 1.07]72%5 studies34,83941,811not evaluable ROB-
Small for gestational age (weight)0.88 [0.59, 1.29]61%2 studies32,41038,030not evaluable ROB-
Very low birth weight (< 1500g)1.18 [0.90, 1.54]-1 study1,1743,458not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Caesarean1.53 [0.92, 2.55]-1 study52158not evaluable ROB-
Maternal consequences (as a whole)2.07 [0.18, 24.23]-1 study329not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low Apgar score (< 7) (at 1 min)1.05 [0.55, 2.01]0%5 studies37282not evaluable ROB-
Low Apgar score (< 7) (at 5 min)1.09 [0.15, 7.97]0%4 studies86not evaluable ROB-
Neonatal death (< 28 days of life)0.48 [0.04, 5.39]-1 study3196not evaluable ROB-
Fetal distress0.62 [0.34, 1.14]-1 study40158not evaluable ROB-
Low Apgar score (< 7) (NOS)1.00 [0.02, 52.85]-1 study21not evaluable ROB-
Neonatal medical care1.02 [0.24, 4.37]-1 study931not evaluable ROB-
Persistent pulmonary hypertension--0 study-
Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation0.33 [0.05, 2.24]-1 study138not evaluable ROB-

Long term consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Child/Infant growth abnormalities (> 1 year)0.96 [0.02, 50.36]-1 study28not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine death (< 22 weeks)0.35 [0.33, 0.38]0%3 studies10,18338,150not evaluable ROB5.15 [.; 4.75]
Late intrauterine deaths (> 22 weeks)0.90 [0.76, 1.08]0%3 studies2,55344,073not evaluable ROB-
Elective/induced termination of pregnancy2.00 [0.77, 5.20]-1 study18175not evaluable ROB-

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Neuro-developmental disorders (as a whole)0.77 [0.49, 1.21]-1 study138149not evaluable ROB-

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