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Pantoprazole
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Diav-Citrin, 2005 Pasternak, 2010
2
1.28
[
0.83
; 1.99]
21,919
591
not evaluable
Major congenital malformations
Diav-Citrin, 2005 Pasternak, 2010
2
1.28
[
0.83
; 1.99]
21,919
591
not evaluable
Growth parameters and prematurity
Low birth weight (< 2500g)
Choi, 2023
1
1.05
[
0.95
; 1.16]
104,454
6,180
not evaluable
Preterm (< 37 weeks)
Diav-Citrin, 2005
1
1.30
[
0.57
; 2.99]
93
48
not evaluable
Intrauterine deaths
Early intrauterine death (< 22 weeks)
Diav-Citrin, 2005
1
0.27
[
0.04
; 1.98]
59
53
not evaluable
Ectopic pregnancy
0
-
-
-
-
-
Elective/induced termination of pregnancy
Diav-Citrin, 2005
1
1.87
[
0.55
; 6.37]
30
53
not evaluable
Late intrauterine deaths (> 22 weeks)
Diav-Citrin, 2005
1
8.33
[
0.74
; 93.34]
3
53
not evaluable
0.0
100.0
1.0