Misoprostol

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations Major congenital malformations Barbero, 2011 Vauzelle, 2013 Auffret, 2016 32.86[1.44; 5.65]36388not evaluable All congenital malformations (majors, minors, majors and minors, or unspecified) Dal Pizzol, 2008 12.64[1.03; 6.76]86118not evaluable Limb defects Orioli, 2000 11.90[0.26; 13.97]3472not evaluable Nervous system anomalies Orioli, 2000 14.23[1.47; 12.16]34145not evaluable Urinary malformations Orioli, 2000 11.60[0.38; 6.74]34176not evaluable Ear, face and neck anomalies Orioli, 2000 10.74[0.18; 3.06]34365not evaluable Limb reduction defects (LRD) Orioli, 2000 Vargas, 2000 215.12[5.53; 41.34]6147not evaluable Moebius syndrome Pastuszak, 1998 Vargas, 2000 232.19[10.54; 98.31]12574not evaluable Oro-facial clefts Orioli, 2000 15.74[1.34; 24.59]3452not evaluable Abdominal wall defects Orioli, 2000 16.36[2.38; 16.96]3423not evaluable Club foot / Talipes equinovarus Orioli, 2000 11.02[0.24; 4.31]34270not evaluable Congenital heart defects Orioli, 2000 13.67[0.49; 27.50]3439not evaluable Vascular disruption anomalie Vargas, 2000 122.00[6.59; 73.42]9344not evaluable Growth parameters and prematurity Preterm (< 37 weeks) Vauzelle, 2013 13.51[1.38; 8.91]20145not evaluable Intrauterine deaths Early intrauterine death (< 22 weeks) Vauzelle, 2013 Andersen (vs diclofenac), 2016 22.16[1.40; 3.34]36296not evaluable Intrauterine deaths (as a whole or unspecified) Barbero, 2011 12.27[1.30; 3.97]4694not evaluable Elective/induced termination of pregnancy Vauzelle, 2013 15.33[2.93; 9.71]74236not evaluable Late intrauterine deaths (> 22 weeks) Vauzelle, 2013 17.66[0.39; 149.14]3236not evaluable Therapeutic terminations of pregnancy Vauzelle, 2013 12.18[0.40; 12.02]6236not evaluable0.0100.01.0

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