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Quetiapine
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
McKenna, 2005 Reis (Unexposed control, NOS), 2008 Peng, 2013 Habermann (Control unexposed, disease free), 2013 Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 Cohen, 2023 Chan (Controls unexposed, sick), 2024
8
1.04
[
0.94
; 1.15]
61,835
9,196
serious
Major congenital malformations
McKenna, 2005 Reis (Unexposed control, NOS), 2008 Peng, 2013 Habermann (Control unexposed, disease free), 2013 Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023 Cohen, 2023 Chan (Controls unexposed, sick), 2024
8
1.04
[
0.94
; 1.15]
61,835
9,196
serious
Congenital heart defects
Huybrechts (Controls unexposed, sick), 2023 Chan (Controls unexposed, sick), 2024
2
1.09
[
0.92
; 1.29]
142
8,519
not evaluable
Ano-rectal atresia and stenosis
Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023
2
1.76
[
0.28
; 10.90]
574
8,569
not evaluable
Gastroschisis
Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023
2
3.72
[
0.44
; 31.72]
246
8,569
not evaluable
Oesophageal atresia with or without tracheo-oesophageal fistula
Raguideau, 2017 Huybrechts (Controls unexposed, sick), 2023
2
1.80
[
0.08
; 39.91]
418
8,569
not evaluable
Digestive system anomalies
Ellfolk (Controls unexposed NOS), 2021
1
0.16
[
0.02
; 1.19]
47
2,618
not evaluable
Hip dislocation and/or dysplasia
Huybrechts (Controls unexposed, sick), 2023
1
0.84
[
0.40
; 1.76]
-
8,350
not evaluable
Hydrocephaly
Huybrechts (Controls unexposed, sick), 2023
1
1.08
[
0.45
; 2.59]
-
8,350
not evaluable
Limb defects
Ellfolk (Controls unexposed NOS), 2021
1
0.67
[
0.38
; 1.19]
261
2,618
not evaluable
Limb reduction defects (LRD)
Huybrechts (Controls unexposed, sick), 2023
1
0.88
[
0.22
; 3.51]
-
8,350
not evaluable
Nervous system anomalies
Ellfolk (Controls unexposed NOS), 2021
1
0.53
[
0.15
; 1.89]
53
2,618
not evaluable
Neural Tube Defects
Huybrechts (Controls unexposed, sick), 2023
1
0.81
[
0.20
; 3.26]
-
8,350
not evaluable
Oro-facial clefts
Huybrechts (Controls unexposed, sick), 2023
1
0.94
[
0.55
; 1.61]
-
8,350
not evaluable
Respiratory system anomalies
Ellfolk (Controls unexposed NOS), 2021
1
0.21
[
0.01
; 3.47]
20
2,618
not evaluable
Atrial septal defect
Raguideau, 2017
1
1.20
[
0.08
; 19.31]
3,582
219
not evaluable
Bilateral renal agenesis including Potter syndrome
Raguideau, 2017
1
57.23
[
3.54
; 926.28]
75
219
not evaluable
Bladder exstrophy and/or epispadia
Raguideau, 2017
1
52.37
[
3.24
; 847.02]
82
219
not evaluable
Cleft lip with or without cleft palate
Raguideau, 2017
1
2.58
[
0.16
; 41.34]
1,675
219
not evaluable
Cleft palate
Raguideau, 2017
1
3.53
[
0.22
; 56.73]
1,221
219
not evaluable
Club foot / Talipes equinovarus
Raguideau, 2017
1
10.40
[
1.85
; 58.45]
1,696
219
not evaluable
Coarctation of aorta
Raguideau, 2017
1
5.23
[
0.33
; 83.98]
825
219
not evaluable
Craniosynostosis
Raguideau, 2017
1
5.55
[
0.35
; 89.06]
778
219
not evaluable
Diaphragmatic hernia
Raguideau, 2017
1
22.20
[
1.53
; 321.20]
395
219
not evaluable
Ebstein's anomaly
Raguideau, 2017
1
82.30
[
5.06
; 1337.43]
52
219
not evaluable
Hypoplastic left heart (HLH/HLHS)
Raguideau, 2017
1
18.19
[
1.13
; 292.60]
237
219
not evaluable
Hypoplastic right heart (HRH/HRHS)
Raguideau, 2017
1
59.59
[
3.68
; 964.97]
72
219
not evaluable
Hypospadias
Raguideau, 2017
1
1.27
[
0.08
; 20.32]
3,404
219
not evaluable
Microcephaly / Small head circumference for gestational age
Raguideau, 2017
1
9.10
[
0.57
; 146.22]
474
219
not evaluable
Multicystic renal dysplasia
Raguideau, 2017
1
6.23
[
0.39
; 99.99]
693
219
not evaluable
Omphalocele
Raguideau, 2017
1
15.24
[
0.95
; 245.00]
283
219
not evaluable
Polydactyly
Raguideau, 2017
1
22.50
[
1.54
; 328.12]
389
219
not evaluable
Pulmonary artery atresia
Raguideau, 2017
1
26.92
[
1.67
; 433.60]
160
219
not evaluable
Spina bifida
Raguideau, 2017
1
6.92
[
0.43
; 111.05]
624
219
not evaluable
Tetralogy of Fallot
Raguideau, 2017
1
6.70
[
0.42
; 107.60]
644
219
not evaluable
Transposition of the great vessels
Raguideau, 2017
1
7.87
[
0.49
; 126.47]
548
219
not evaluable
Ventricular septal defect
Raguideau, 2017
1
0.86
[
0.05
; 13.80]
5,009
219
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Newport, 2007 Vigod, 2015 Ozturk, 2016 Kananen, 2023
4
1.17
[
0.91
; 1.50]
2,413
734
not evaluable
Large for gestational age (weight)
Vigod, 2015 Kananen, 2023
2
1.36
[
0.68
; 2.72]
1,009
708
not evaluable
Small for gestational age (weight)
Vigod, 2015 Kananen, 2023
2
1.09
[
0.73
; 1.64]
967
708
not evaluable
Low birth weight (< 2500g)
Newport, 2007
1
1.92
[
0.07
; 51.03]
1
21
not evaluable
Macrosomia (> 4000g)
Newport, 2007
1
0.19
[
0.01
; 4.97]
1
21
not evaluable
Maternal consequences
Gestational diabetes
Vigod, 2015 Park, 2018 Wang - UK cohort, 2021 Wang - HK cohort, 2021 Kulkarni, 2024
5
1.30
[
1.06
; 1.58]
442
2,145
not evaluable
Assisted deliveries (forceps, vacuum, ...)
Kananen, 2023
1
0.69
[
0.32
; 1.49]
2,422
152
not evaluable
Caesarean
0
-
-
-
-
-
Postpartum hemorrhage
Kananen, 2023
1
1.65
[
1.13
; 2.41]
6,930
152
not evaluable
Preeclampsia
Vigod, 2015
1
1.19
[
0.73
; 1.95]
69
556
not evaluable
Neonatal disorders
Neonatal medical care
Newport, 2007 Kananen, 2023
2
1.15
[
0.80
; 1.65]
5,511
173
not evaluable
Neonatal death (< 28 days of life)
Källen, 2013 Kananen, 2023
2
2.00
[
1.45
; 2.75]
29
209
not evaluable
Neonatal disorders (as a whole)
Habermann (Control unexposed, disease free), 2013
1
7.85
[
4.12
; 14.98]
59
62
not evaluable
Infant health status
Wurtz, 2017
1
0.99
[
0.92
; 1.07]
-
-
not evaluable
Low Apgar score (< 7) (at 5 min)
Kananen, 2023
1
1.05
[
0.60
; 1.83]
1,624
152
not evaluable
Intrauterine deaths
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions
Yaris, 2005 Sorensen, 2015 Ozturk, 2016 Ishikawa, 2024
4
1.32
[
0.79
; 2.22]
158,498
372
not evaluable
Elective/induced termination of pregnancy
Ozturk, 2016
1
11.19
[
2.42
; 51.61]
17
8
not evaluable
Intrauterine deaths (as a whole or unspecified)
Kulkarni, 2024
1
1.52
[
0.06
; 38.67]
1
48
not evaluable
Late intrauterine deaths (> 22 weeks) / Stillbirths
Kananen, 2023
1
2.13
[
0.30
; 15.34]
110
152
not evaluable
Neuro-developmental disorders
Cognitive developmental disorders/delay (> 6 years old)
Straub, 2022 Bruno, 2024
2
0.94
[
0.56
; 1.57]
4,218
7,821
not evaluable
Language disorders/delay
Straub, 2022 Bruno, 2024
2
1.10
[
0.96
; 1.25]
78,721
8,351
not evaluable
Learning disorders
Straub, 2022 Bruno, 2024
2
1.16
[
0.85
; 1.58]
6,841
7,821
not evaluable
Neuro-developmental disorders (as a whole)
Straub, 2022 Bruno, 2024
2
1.09
[
0.99
; 1.19]
160,701
8,949
not evaluable
Severe cognitive developmental delay (Mental retardation) (> 6 years old)
Straub, 2022 Bruno, 2024
2
0.94
[
0.56
; 1.57]
4,218
7,821
not evaluable
ADHD (Attention deficit hyperactivity disorder): Diagnosis
Straub, 2022
1
1.08
[
0.91
; 1.28]
62,525
4,457
not evaluable
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk
Straub, 2022
1
1.08
[
0.91
; 1.28]
62,525
4,457
not evaluable
ASD (Autism spectrum disorder): Diagnosis
Straub, 2022
1
1.12
[
0.81
; 1.54]
13,474
4,457
not evaluable
ASD (Autism spectrum disorder): Diagnosis/Risk
Straub, 2022
1
1.12
[
0.81
; 1.54]
13,474
4,457
not evaluable
Psychomotor developmental disorders/delay
Straub, 2022
1
1.03
[
0.69
; 1.54]
11,877
4,457
not evaluable
0.0
100.0
1.0
