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Carvedilol (versus unexposed)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Delteil, 2024
1
39.89
[
0.79
; 2010.55]
4,054
1
not evaluable
Major congenital malformations
Delteil, 2024
1
39.89
[
0.79
; 2010.55]
4,054
1
not evaluable
Growth parameters and prematurity
Small for gestational age (weight)
Tanaka, 2016 Kubota - Carvedilol, 2023
2
2.36
[
0.83
; 6.69]
23
45
not evaluable
Preterm (< 37 weeks)
Tanaka, 2016
1
2.02
[
0.56
; 7.31]
22
13
not evaluable
Maternal consequences
Caesarean
Tanaka, 2016 Kubota - Carvedilol, 2023
2
9.34
[
3.23
; 26.99]
226
45
not evaluable
Assisted deliveries (forceps, vacuum, ...)
Kubota - Carvedilol, 2023
1
0.63
[
0.03
; 11.39]
6
32
not evaluable
Neonatal disorders
Neonatal death (< 28 days of life)
Tanaka, 2016
1
7.96
[
0.15
; 419.18]
-
13
not evaluable
0.0
100.0
1.0
