Fluconazole (all routes except local only) - Cumulative dose > 150 mg

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Molgaard-Nielsen (300 - 6000mg), 2013 Berard (> 150 mg), 2019 21.20[0.99; 1.46]44,7503,670not evaluable Limb defects Molgaard-Nielsen (300 - 6000mg), 2013 Berard (> 150 mg), 2019 21.18[0.80; 1.75]12,4413,670not evaluable Cleft lip with or without cleft palate Molgaard-Nielsen (300 - 6000mg), 2013 11.26[0.42; 3.77]1,2693,270not evaluable Cleft palate Molgaard-Nielsen (300 - 6000mg), 2013 11.69[0.39; 7.30]5003,270not evaluable Congenital heart defects Molgaard-Nielsen (300 - 6000mg), 2013 11.06[0.67; 1.68]7,8673,270not evaluable Eye defects Berard (> 150 mg), 2019 11.50[0.37; 6.11]728400not evaluable Genital anomalies Berard (> 150 mg), 2019 12.30[0.94; 5.62]1,179400not evaluable Major congenital malformations Molgaard-Nielsen (300 - 6000mg), 2013 Berard (> 150 mg), 2019 21.20[0.99; 1.46]44,7503,670not evaluable Nervous system anomalies Berard (> 150 mg), 2019 11.97[0.72; 5.39]899400not evaluable Tetralogy of Fallot Molgaard-Nielsen (300 - 6000mg), 2013 13.20[0.74; 13.82]2903,270not evaluable Urinary malformations Berard (> 150 mg), 2019 11.41[0.62; 3.22]2,203400not evaluable Ventricular septal defect Molgaard-Nielsen (300 - 6000mg), 2013 11.55[0.84; 2.86]3,1893,270not evaluable Cardiac septal defects Berard (> 150 mg), 2019 11.81[1.04; 3.15]3,282400not evaluable Craniosynostosis Molgaard-Nielsen (300 - 6000mg), 2013 11.94[0.65; 5.80]7213,270not evaluable Digestive system anomalies Berard (> 150 mg), 2019 11.95[0.60; 6.33]625400not evaluable Hypoplastic left heart (HLH/HLHS) Molgaard-Nielsen (300 - 6000mg), 2013 12.33[0.33; 16.58]-2,252not evaluable Polydactyly Molgaard-Nielsen (300 - 6000mg), 2013 12.71[1.01; 7.27]-2,252not evaluable Syndactyly Molgaard-Nielsen (300 - 6000mg), 2013 10.62[0.09; 4.34]-2,252not evaluable Neonatal disorders Neonatal death (< 28 days of life) Pasternak (>300 mg), 2018 10.66[0.27; 1.61]1824,530not evaluable Intrauterine deaths Early intrauterine deaths (< 22 weeks) / Spontaneous abortions Inman (> 150mg), 1994 Molgaard-Nielsen (> 350-5600), 2016 Berard (> 150 mg), 2019 32.42[1.28; 4.56]30,0701,238not evaluable Late intrauterine deaths (> 22 weeks) / Stillbirths Molgaard-Nielsen (> 350-5600), 2016 Pasternak (>300 mg), 2018 Berard (> 150 mg), 2019 31.31[0.32; 5.34]1,1955,153not evaluable0.020.01.0

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