metaPreg - Fluconazole (all routes except local only) - Cumulative dose > 150 mg during pregnancy

Fluconazole (all routes except local only) - Cumulative dose > 150 mg updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.20 [0.99, 1.46]	0%	2 studies	44,750	3,670	not evaluable	ROB	-
Limb defects	1.18 [0.80, 1.75]	0%	2 studies	12,441	3,670	not evaluable	ROB	-
Major congenital malformations	1.20 [0.99, 1.46]	0%	2 studies	44,750	3,670	not evaluable	ROB	-
Cardiac septal defects	1.81 [1.04, 3.15]	-	1 study	3,282	400	not evaluable	ROB	3.02 [1.25; .]
Polydactyly	2.71 [1.01, 7.27]	-	1 study		2,252	not evaluable	ROB	4.86 [1.11; .]
13 non statistically significant endpoints reported in only one study
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
1 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	2.42 [1.28, 4.56]	73%	3 studies	30,070	1,238	not evaluable	ROB	4.27 [1.88; .]
Late intrauterine deaths (> 22 weeks) / Stillbirths	1.31 [0.32, 5.34]	85%	3 studies	1,195	5,153	not evaluable	ROB	-