Ondansetron

Table   Graphic  
  individual studies
OutcomeTE95% CIn casesn exposedkPub. bias All congenital malformations (majors, minors, majors and minors, or unspecified) Einarson (Unexposed control), 2004 Andersen, 2013 Ozdemirci, 2014 Danielsson, 2014 Fejzo (Unexposed control, disease free), 2016 Huybrechts (Unexposed control), 2018 Bérard, 2019 Huybrechts, 2019 81.04[0.96; 1.12]167,592116,161not evaluable Cleft lip with or without cleft palate Anderka, 2012 Pasternak, 2013 Fejzo (Unexposed control, disease free), 2016 Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 Parker, NBDPS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 71.03[0.88; 1.21]4,58592,238not evaluable Congenital heart defects Andersen, 2013 Danielsson, 2014 Fejzo (Unexposed control, disease free), 2016 Huybrechts (Unexposed control), 2018 Zambelli-Weiner (Unexposed control, sick), 2019 Huybrechts, 2019 61.13[0.96; 1.33]59,616116,155not evaluable Major congenital malformations Einarson (Unexposed control), 2004 Andersen, 2013 Colvin, 2013 Danielsson, 2014 Huybrechts (Unexposed control), 2018 Bérard, 2019 Huybrechts, 2019 71.02[0.99; 1.05]150,947115,320not evaluable Ventricular septal defect Pasternak, 2013 Fejzo (Unexposed control, disease free), 2016 Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 Parker, NBDPS study, 2018 Lemon, 2019 Zambelli-Weiner (Unexposed control, NOS), 2019 71.13[0.99; 1.27]19,11096,086not evaluable Cleft palate Anderka, 2012 Pasternak, 2013 Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 Parker, NBDPS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 61.26[0.87; 1.82]3,36391,261not evaluable Atrial septal defect Pasternak, 2013 Parker, BDS study, 2018 Parker, NBDPS study, 2018 Huybrechts (Unexposed control), 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 51.05[0.79; 1.39]5,71591,265not evaluable Hypospadias Anderka, 2012 Lind (Controls unexposed, NOS), 2013 Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 50.90[0.70; 1.15]3,3231,874not evaluable Oro-facial clefts Pasternak, 2013 Huybrechts (Unexposed control), 2018 Zambelli-Weiner (Unexposed control, sick), 2019 Huybrechts, 2019 41.20[1.02; 1.40]3,506113,549not evaluable Atrioventricular septal defect Pasternak, 2013 Parker, NBDPS study, 2018 Huybrechts (Unexposed control), 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 41.38[0.65; 2.93]6,19090,765not evaluable Club foot / Talipes equinovarus Pasternak, 2013 Werler, 2014 Fejzo (Unexposed control, disease free), 2016 Parker, BDS study, 2018 41.09[0.83; 1.44]1,0612,714not evaluable Limb defects Pasternak, 2013 Parker, NBDPS study, 2018 Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 41.02[0.92; 1.11]8,42590,330not evaluable Ano-rectal atresia and stenosis Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 30.79[0.49; 1.27]6711,881not evaluable Atresia or stenosis of other parts of small intestine Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 30.97[0.61; 1.53]3941,880not evaluable Coarctation of aorta Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 30.95[0.69; 1.29]8441,903not evaluable Diaphragmatic hernia Pasternak, 2013 Parker, NBDPS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 31.70[1.17; 2.48]8752,394not evaluable Gastroschisis Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 30.89[0.61; 1.29]9591,894not evaluable Hypoplastic left heart Parker, NBDPS study, 2018 Parker, BDS study, 2018 Zambelli-Weiner (Unexposed control, NOS), 2019 31.49[1.03; 2.17]8381,539not evaluable Pulmonary valve stenosis Pasternak, 2013 Parker, NBDPS study, 2018 Parker, BDS study, 2018 31.08[0.79; 1.48]1,0251,913not evaluable Severe congenital heart defect Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 20.76[0.63; 0.93]1,88088,851not evaluable Single ventricle Parker, NBDPS study, 2018 Huybrechts (Unexposed control), 2018 20.90[0.34; 2.37]42488,706not evaluable Total anomalous pulm venous return Parker, NBDPS study, 2018 Huybrechts (Unexposed control), 2018 20.84[0.55; 1.30]50288,705not evaluable Abdominal wall defects Pasternak, 2013 Huybrechts (Unexposed control), 2018 20.98[0.90; 1.07]8,81689,679not evaluable Bilateral renal agenesis including Potter syndrome Pasternak, 2013 Parker, BDS study, 2018 21.85[1.13; 3.02]1611,630not evaluable Cardiac septal defects Danielsson, 2014 Zambelli-Weiner (Unexposed control, NOS), 2019 21.57[1.17; 2.12]39,4752,528not evaluable Congenital cataract Pasternak, 2013 Parker, NBDPS study, 2018 20.94[0.46; 1.91]2111,494not evaluable Digestive system anomalies Pasternak, 2013 Huybrechts (Unexposed control), 2018 20.93[0.85; 1.02]9,59889,700not evaluable Eye defects Pasternak, 2013 Huybrechts (Unexposed control), 2018 20.95[0.69; 1.30]77289,700not evaluable Genital anomalies Pasternak, 2013 Huybrechts (Unexposed control), 2018 21.06[0.97; 1.17]7,10089,679not evaluable Limb reduction defects Pasternak, 2013 Zambelli-Weiner (Unexposed control, NOS), 2019 21.01[0.39; 2.58]5632,115not evaluable Nervous system anomalies Pasternak, 2013 Huybrechts (Unexposed control), 2018 20.94[0.81; 1.09]3,49689,679not evaluable Oesophageal atresia with or without tracheo-oesophageal fistula Pasternak, 2013 Parker, NBDPS study, 2018 20.71[0.40; 1.28]3641,496not evaluable Patent ductus arterious Huybrechts (Unexposed control), 2018 10.90[0.73; 1.11]1,67588,446not evaluable Respiratory system anomalies Pasternak, 2013 Huybrechts (Unexposed control), 2018 21.13[1.01; 1.27]3,95189,679not evaluable Spina bifida Parker, NBDPS study, 2018 Parker, BDS study, 2018 21.24[0.83; 1.83]461620not evaluable Transposition of the great vessels Parker, NBDPS study, 2018 Parker, BDS study, 2018 20.80[0.52; 1.23]584649not evaluable Urinary malformations Pasternak, 2013 Huybrechts (Unexposed control), 2018 21.24[0.76; 2.01]17689,679not evaluable Anophthalmos/micropthalmos Parker, NBDPS study, 2018 10.90[0.31; 2.65]132257not evaluable Anotia Parker, NBDPS study, 2018 11.10[0.59; 2.06]354263not evaluable Aortic valve atresia/stenosis Parker, NBDPS study, 2018 10.50[0.20; 1.22]272260not evaluable Atresia of bile ducts Parker, NBDPS study, 2018 11.30[0.51; 3.29]101258not evaluable Choanal atresia Pasternak, 2013 11.33[0.05; 32.76]11,233not evaluable Congenital constriction bands/amniotic band Parker, NBDPS study, 2018 11.30[0.51; 3.29]155258not evaluable Congenital glaucoma Pasternak, 2013 14.00[0.25; 64.04]21,233not evaluable Congenital hydronephrosis Pasternak, 2013 10.80[0.17; 3.65]121,233not evaluable Congenital skin disorders Pasternak, 2013 10.57[0.03; 11.07]31,233not evaluable Ear malformations Huybrechts (Unexposed control), 2018 11.67[1.17; 2.38]45088,446not evaluable Ear, face and neck anomalies Pasternak, 2013 14.00[0.25; 64.04]21,233not evaluable Ebstein's anomaly Parker, NBDPS study, 2018 11.10[0.39; 3.11]108257not evaluable Hirschsprung's disease Parker, BDS study, 2018 11.20[0.60; 2.40]110385not evaluable0.0100.01.0