Thiouracil, propylthiouracil, benzylthiouracil

Table   Graphic  
  individual studies
OutcomeTE95% CIn casesn exposedkPub. bias All congenital malformations (majors, minors, majors and minors, or unspecified) 100.99[0.80; 1.24]249,61412,690low Major congenital malformations 50.69[0.45; 1.06]1091,638not evaluable Genital anomalies 31.22[0.96; 1.54]25,81111,037not evaluable Respiratory system anomalies 31.22[0.76; 1.96]16,00711,037not evaluable Urinary malformations 31.63[1.01; 2.62]17,69611,037not evaluable Eye defects 20.44[0.06; 3.31]2,4841,107not evaluable Congenital heart defects 31.05[0.84; 1.31]77,56811,037not evaluable Limb defects 31.20[1.05; 1.37]74,70611,037not evaluable Severe congenital heart defect 21.20[0.06; 22.67]7391,446not evaluable Abdominal wall defects 21.19[0.15; 9.65]9261,107not evaluable Carbimazole embryopathy 31.61[0.92; 2.79]2,24311,423not evaluable Digestive system anomalies 21.47[0.59; 3.67]12,04510,148not evaluable Nervous system anomalies 21.09[0.72; 1.65]5,86810,148not evaluable Syndromes and chromosomal abnormalities 20.84[0.33; 2.12]5,5471,107not evaluable Ano-rectal atresia and stenosis 22.87[0.24; 33.74]1,0551,413not evaluable Aortic valve atresia/stenosis 23.29[0.12; 89.46]4941,412not evaluable Cardiac septal defects 0----- Ear malformations 135.97[1.72; 751.88]2218not evaluable Ear, face and neck anomalies 12.86[0.55; 14.85]7218not evaluable Omphalocele 21.29[0.13; 12.49]1541,446not evaluable Other congenital malformations (Q80-84) 10.37[0.02; 6.43]9218not evaluable Situs inversus 215.05[1.80; 126.08]271,446not evaluable Aplasia cutis congenita 11.36[0.03; 68.71]-1,399not evaluable Atresia of bile ducts 10.45[0.02; 11.15]11,399not evaluable Atresia or stenosis of other parts of small intestine 11.36[0.03; 68.71]-1,399not evaluable Atrial septal defect 12.73[0.25; 30.11]31,399not evaluable Brachydactyly 14.09[0.17; 100.49]11,399not evaluable Chromosomal abnormalities 14.02[0.55; 29.24]452not evaluable Cleft lip with or without cleft palate 10.68[0.06; 7.52]31,399not evaluable Club foot / Talipes equinovarus 10.45[0.02; 11.15]11,399not evaluable Congenital cataract 10.45[0.02; 11.15]11,399not evaluable Congenital hydronephrosis 16.82[0.33; 142.23]21,399not evaluable Diaphragmatic hernia 10.45[0.02; 11.15]11,399not evaluable Down syndrom / Trisomy 21 11.36[0.19; 9.69]41,399not evaluable Eye, ear, face and neck malformations 11.21[0.89; 1.64]9,4849,930not evaluable Hypospadias 14.09[0.17; 100.49]11,399not evaluable Intestinal malrotation 10.45[0.05; 4.37]41,399not evaluable Multicystic renal dysplasia 10.45[0.02; 11.15]11,399not evaluable Oesophageal atresia with or without tracheo-oesophageal fistula 11.36[0.03; 68.71]-1,399not evaluable Oro-facial clefts 10.98[0.56; 1.72]3,4589,930not evaluable Other congenital malformations (Q80 to Q99) 11.14[0.84; 1.55]10,0649,930not evaluable Patent ductus arterious 14.09[0.17; 100.49]11,399not evaluable Pulmonary artery stenosis 10.45[0.02; 11.15]11,399not evaluable Skeletal dysplasia 10.45[0.02; 11.15]11,399not evaluable Spina bifida 14.09[0.17; 100.49]11,399not evaluable Sturge-Weber syndrome 11.36[0.03; 68.71]-1,399not evaluable Syndactyly 14.09[0.43; 39.40]41,399not evaluable Tetralogy of Fallot 14.09[0.17; 100.49]11,399not evaluable Transposition of the great vessels 10.45[0.02; 11.15]11,399not evaluable Ventricular septal defect 10.99[0.40; 2.47]191,399not evaluable0.0100.01.0