meta
|
Preg
- medecines during pregnancy KB
Search
Lansoprazole
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Paternal exp. genotoxic window only (0–3 months preconception)
Paternal exposure: epigenetic window only (3–xxx months preconception)
Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)
Paternal exposure: other window
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Diav-Citrin, 2005 Pasternak, 2010 Matok, 2012 Choi a, 2023 Broe (Controls unexposed, sick), 2025 Hongoh, 2025
6
1.08
[
0.96
; 1.21]
115,310
11,105
not evaluable
Major congenital malformations
Diav-Citrin, 2005 Pasternak, 2010 Matok, 2012 Choi a, 2023 Broe (Controls unexposed, sick), 2025 Hongoh, 2025
6
1.08
[
0.96
; 1.21]
115,310
11,105
not evaluable
Hypospadias
Källèn, 1998 Lind, 2013 Choi a, 2023
3
1.57
[
0.70
; 3.51]
3,342
3,309
not evaluable
Genetic syndromes and microdeletions
Broe (Controls unexposed, sick), 2025
1
1.43
[
0.69
; 2.97]
31
3,534
not evaluable
Atrial septal defect
Källèn, 1998
1
49.70
[
1.92
; 1288.78]
1
13
not evaluable
Cleft palate
Choi a, 2023
1
1.00
[
0.45
; 2.25]
2,287
6,404
not evaluable
Congenital heart defects
Choi a, 2023
1
0.96
[
0.80
; 1.16]
42,269
6,404
not evaluable
Congenital hydronephrosis
Källèn, 1998
1
5.05
[
0.20
; 130.52]
1
13
not evaluable
Down syndrom / Trisomy 21
Källèn, 1998
1
15.24
[
0.29
; 800.69]
-
13
not evaluable
Encephalocele
Källèn, 1998
1
5.05
[
0.20
; 130.52]
1
13
not evaluable
Hydrocephaly
Choi a, 2023
1
0.94
[
0.23
; 3.81]
786
6,404
not evaluable
Patent ductus arterious
Källèn, 1998
1
15.24
[
0.29
; 800.69]
-
13
not evaluable
Ventricular septal defect
Källèn, 1998
1
15.24
[
0.29
; 800.69]
-
13
not evaluable
Growth parameters and prematurity
Low birth weight (< 2500g)
Choi b, 2023 Hongoh, 2025
2
0.91
[
0.83
; 1.00]
104,657
8,774
not evaluable
Preterm (< 37 weeks)
Diav-Citrin, 2005 Hongoh, 2025
2
1.64
[
0.93
; 2.88]
164
144
not evaluable
Long term consequences
Childhood asthma
Yitshak-Sade, 2016
1
1.70
[
1.38
; 2.09]
-
346
not evaluable
Intrauterine deaths
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions
Diav-Citrin, 2005 Hongoh, 2025
2
1.39
[
0.75
; 2.57]
149
168
not evaluable
Elective/induced termination of pregnancy
Diav-Citrin, 2005 Hongoh, 2025
2
3.79
[
1.85
; 7.76]
52
168
not evaluable
Late intrauterine deaths (> 22 weeks) / Stillbirths
Diav-Citrin, 2005 Hongoh, 2025
2
1.91
[
0.23
; 15.48]
8
159
not evaluable
Ectopic pregnancy
0
-
-
-
-
-
Neuro-developmental disorders
Neuro-developmental disorders (as a whole)
Fejzo, 2015
1
2.00
[
0.87
; 4.60]
138
25
not evaluable
0.0
100.0
1.0
