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Nifedipine (versus unexposed)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Weber-Schoendorfer, 2008
1
1.31
[
0.39
; 4.42]
36
51
not evaluable
Limb defects
Weber-Schoendorfer, 2008
1
2.04
[
0.10
; 39.95]
3
51
not evaluable
Major congenital malformations
Weber-Schoendorfer, 2008
1
2.07
[
0.46
; 9.35]
16
51
not evaluable
Oesophageal atresia with or without tracheo-oesophageal fistula
Vermes, 2015
1
3.27
[
0.98
; 10.93]
221
9
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Parazzini, 1998 Weber-Schoendorfer, 2008
2
2.97
[
0.54
; 16.34]
172
180
not evaluable
Low birth weight (< 2500g)
Parazzini, 1998
1
1.09
[
0.64
; 1.87]
77
129
not evaluable
Very low birth weight (< 1500g)
Parazzini, 1998
1
1.20
[
0.48
; 2.99]
20
129
not evaluable
Very preterm (28 to 32 weeks)
Parazzini, 1998
1
1.60
[
0.79
; 3.25]
33
129
not evaluable
Maternal consequences
Caesarean
Parazzini, 1998
1
0.70
[
0.42
; 1.16]
149
128
not evaluable
Neonatal disorders
Neonatal death (< 28 days of life)
Parazzini, 1998
1
0.98
[
0.14
; 7.04]
4
132
not evaluable
Neonatal medical care
Parazzini, 1998
1
1.80
[
0.70
; 4.61]
19
123
not evaluable
Infant health status
Bortolus, 2000
1
6.49
[
0.34
; 122.60]
4
94
not evaluable
Long term consequences
Child/Infant death (> 28 days of life)
Bortolus, 2000
1
0.23
[
0.01
; 5.65]
1
94
not evaluable
Child/Infant lenght abnormalities (> 1 year)
Bortolus, 2000
1
0.38
[
0.13
; 1.09]
16
94
not evaluable
Child/Infant weight abnormalities (> 1 year)
Bortolus, 2000
1
1.28
[
0.53
; 3.10]
25
94
not evaluable
Intrauterine deaths
Early intrauterine death (< 22 weeks)
Parazzini, 1998 Weber-Schoendorfer, 2008
2
1.08
[
0.10
; 11.26]
72
197
not evaluable
Late intrauterine deaths (> 22 weeks)
Parazzini, 1998 Weber-Schoendorfer, 2008
2
3.40
[
0.85
; 13.63]
14
197
not evaluable
Elective/induced termination of pregnancy
Weber-Schoendorfer, 2008
1
4.38
[
2.10
; 9.14]
41
76
not evaluable
Therapeutic terminations of pregnancy
Parazzini, 1998
1
0.98
[
0.06
; 15.79]
2
132
not evaluable
Neuro-developmental disorders
Language disorders/delay
Bortolus, 2000
1
1.27
[
0.41
; 3.98]
14
94
not evaluable
Psychomotor developmental disorders/delay
Bortolus, 2000
1
0.92
[
0.20
; 4.25]
7
94
not evaluable
0.0
100.0
1.0
