Bisoprolol (versus unexposed)

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Hoeltzenbein, 2018 Delteil, 2024 21.72[0.35; 8.42]4,098363not evaluable Major congenital malformations Hoeltzenbein, 2018 Delteil, 2024 21.72[0.35; 8.42]4,098363not evaluable Growth parameters and prematurity Small for gestational age (weight) Tanaka, 2016 Fitton (Controls unexposed, sick), 2020 21.54[0.95; 2.51]1,082111not evaluable Low birth weight (< 2500g) Ishibashi, 2017 Vaclavik, 2024 25.28[0.66; 42.46]2164not evaluable Preterm (< 37 weeks) Hoeltzenbein, 2018 Vaclavik, 2024 22.00[1.57; 2.54]88344not evaluable Maternal consequences Caesarean Vaclavik, 2024 12.08[1.72; 2.52]-175not evaluable Preeclampsia Hoeltzenbein, 2018 12.44[1.01; 5.89]24172not evaluable Neonatal disorders Low Apgar score (< 7) (NOS) Vaclavik, 2024 11.76[1.37; 2.26]-76not evaluable Intrauterine deaths Early intrauterine death (< 22 weeks) Hoeltzenbein, 2018 11.06[0.66; 1.70]85339not evaluable Elective/induced termination of pregnancy Hoeltzenbein, 2018 10.80[0.40; 1.60]47339not evaluable Late intrauterine deaths (> 22 weeks) Hoeltzenbein, 2018 13.02[0.50; 18.15]5339not evaluable0.250.01.0

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