metaPreg - Bisoprolol (versus unexposed) during pregnancy

Bisoprolol (versus unexposed) updated on 12-17-2024

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.72 [0.35, 8.42]	86%	2 studies	4,098	363	not evaluable	ROB	-
Major congenital malformations	1.72 [0.35, 8.42]	86%	2 studies	4,098	363	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Small for gestational age (weight)	1.54 [0.95, 2.51]	0%	2 studies	1,082	111	not evaluable	ROB	-
Low birth weight (< 2500g)	5.28 [0.66, 42.46]	84%	2 studies	21	64	not evaluable	ROB	-
Preterm (< 37 weeks)	2.00 [1.57, 2.54]	0%	2 studies	88	344	not evaluable	ROB	3.41 [2.52; .]
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Caesarean	2.08 [1.72, 2.52]	-	1 study		175	not evaluable	ROB	3.58 [2.83; .]
Preeclampsia	2.44 [1.01, 5.89]	-	1 study	24	172	not evaluable	ROB	4.31 [1.11; .]
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low Apgar score (< 7) (NOS)	1.76 [1.37, 2.26]	-	1 study		76	not evaluable	ROB	2.92 [2.09; .]
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
3 non statistically significant endpoints reported in only one study