Lorazepam updated on 02-10-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Ano-rectal atresia and stenosis3.29 [0.48, 22.44]49%2 studies1,3087not evaluable ROB-
Cleft lip with or without cleft palate2.10 [0.61, 7.27]-1 study3,08611not evaluable ROB-
Cleft palate1.04 [0.13, 8.49]-1 study1,5788not evaluable ROB-
Congenital heart defects1.15 [0.94, 1.41]0%2 studies95,8802,489not evaluable ROB-
All congenital malformations (majors, minors, majors and minors, or unspecified)1.00 [0.85, 1.18]-1 study157,0502,468not evaluable ROB-
Anophthalmos/micropthalmos7.19 [0.88, 58.68]-1 study2308not evaluable ROB-
Anotia2.41 [0.30, 19.59]-1 study6858not evaluable ROB-
Aortic valve atresia/stenosis3.23 [0.40, 26.34]-1 study5108not evaluable ROB-
Atrial septal defect1.60 [0.40, 6.35]-1 study3,02510not evaluable ROB-
Atrioventricular septal defect2.09 [0.12, 36.58]-1 study3697not evaluable ROB-
Cardiac septal defects1.10 [0.30, 4.07]-1 study4,67310not evaluable ROB-
Coarctation of aorta2.86 [0.59, 13.79]-1 study1,1539not evaluable ROB-
Craniosynostosis2.09 [0.43, 10.06]-1 study1,5799not evaluable ROB-
Diaphragmatic hernia0.89 [0.05, 15.54]-1 study8677not evaluable ROB-
Gastroschisis3.50 [0.90, 13.66]-1 study1,40010not evaluable ROB-
Hydrocephaly1.50 [0.09, 26.29]-1 study5137not evaluable ROB-
Major congenital malformations1.00 [0.85, 1.18]-1 study157,0502,468not evaluable ROB-
Neural Tube Defects1.57 [0.33, 7.54]-1 study2,1059not evaluable ROB-
Oesophageal atresia with or without tracheo-oesophageal fistula2.19 [0.27, 17.82]-1 study7538not evaluable ROB-
Omphalocele1.77 [0.10, 31.09]-1 study4347not evaluable ROB-
Oro-facial clefts--0 study-
Pulmonary valve stenosis4.10 [1.19, 14.10]-1 study1,53211not evaluable ROB7.67 [1.67; .]
Spina bifida0.62 [0.04, 10.85]-1 study1,2417not evaluable ROB-
Tetralogy of Fallot2.76 [0.57, 13.29]-1 study1,1969not evaluable ROB-
Transposition of the great vessels4.32 [0.90, 20.81]-1 study7659not evaluable ROB-
Ventricular septal defect0.47 [0.03, 8.17]-1 study1,6487not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)2.99 [0.46, 19.38]98%2 studies263,49511,093not evaluable ROB-
Small for gestational age (weight)1.18 [1.11, 1.25]-1 study263,22111,020not evaluable ROB1.64 [1.46; .]

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions1.48 [1.23, 1.79]54%3 studies45,219896not evaluable ROB2.33 [1.75; .]
Late intrauterine deaths (> 22 weeks) / Stillbirths1.31 [1.11, 1.54]-1 study30,85811,182not evaluable ROB1.95 [1.47; .]

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