metaPreg - Imipramine during pregnancy

Imipramine updated on 10-20-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.23 [0.17, 9.15]	68%	2 studies	31,381	17	not evaluable	ROB	-
Major congenital malformations	0.99 [0.14, 7.09]	47%	2 studies	30,830	14	not evaluable	ROB	-
Minor congenital malformations	3.04 [0.82, 11.25]	-	1 study	551	12	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Large for gestational age (weight)	1.27 [0.40, 4.05]	-	1 study	9,747	64	not evaluable	ROB	-
Low birth weight (< 2500g)	0.74 [0.30, 1.84]	-	1 study	31,352	64	not evaluable	ROB	-
Preterm (< 37 weeks)	1.28 [0.61, 2.68]	-	1 study	28,551	64	not evaluable	ROB	-
Small for gestational age (weight)	2.08 [0.65, 6.66]	-	1 study	6,989	64	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Assisted deliveries (forceps, vacuum, ...)	0.95 [0.38, 2.37]	-	1 study	46,041	64	not evaluable	ROB	-
Caesarean	1.34 [0.81, 2.22]	-	1 study	111,664	64	not evaluable	ROB	-
Maternal consequences (as a whole)	1.20 [0.67, 2.14]	-	1 study	311,142	64	not evaluable	ROB	-
Postpartum hemorrhage	0.89 [0.22, 3.62]	-	1 study	19,757	64	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low Apgar score (< 7) (at 1 min)	0.36 [0.05, 2.58]	-	1 study	14,884	64	not evaluable	ROB	-
Low Apgar score (< 7) (at 5 min)	2.11 [0.13, 34.15]	-	1 study	1,721	64	not evaluable	ROB	-
Neonatal death (< 28 days of life)	5.81 [0.36, 93.97]	-	1 study	627	64	not evaluable	ROB	-
Neonatal disorders (as a whole)	2.41 [1.43, 4.06]	-	1 study	161,448	64	not evaluable	ROB	4.25 [2.21; .]
Neonatal medical care	1.41 [0.44, 4.51]	-	1 study	8,569	64	not evaluable	ROB	-
Long term consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Child/Infant death (> 28 days of life)	27.95 [1.72, 454.24]	-	1 study	130	64	not evaluable	ROB	55.41 [2.83; .]
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	1.19 [0.65, 2.18]	-	1 study			not evaluable	ROB	-
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