metaPreg - Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg during pregnancy

Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.03 [0.89, 1.19]	0%	3 studies	44,784	5,229	not evaluable	ROB	-
Limb defects	0.84 [0.54, 1.30]	31%	3 studies	12,443	5,229	not evaluable	ROB	-
Congenital heart defects	1.29 [0.96, 1.74]	0%	2 studies	7,885	4,316	not evaluable	ROB	-
Major congenital malformations	1.03 [0.89, 1.19]	0%	3 studies	44,784	5,229	not evaluable	ROB	-
Polydactyly	0.71 [0.16, 3.07]	0%	2 studies	599	4,316	not evaluable	ROB	-
Tetralogy of Fallot	3.18 [1.18, 8.56]	-	1 study	291	4,082	not evaluable	ROB	5.81 [1.64; .]
16 non statistically significant endpoints reported in only one study
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	1.09 [0.23, 5.14]	90%	2 studies	29,496	1,759	not evaluable	ROB	-
Ectopic pregnancy	-	-	0 study					-
2 non statistically significant endpoints reported in only one study